Local field potential recordings from the pedunculopontine nucleus in a Parkinsonian patient

TY - JOUR

T1 - Local field potential recordings from the pedunculopontine nucleus in a Parkinsonian patient

AU - Androulidakis, Alexandros G.

AU - Khan, Sadaquate

AU - Litvak, Vladimir

AU - Pleydell-Pearce, Christopher W.

AU - Brown, Peter

AU - Gill, Steven S.

PY - 2008/1/8

Y1 - 2008/1/8

N2 - The pedunculopontine nucleus has recently been introduced as a new therapeutic target for deep brain stimulation in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. Therefore, we looked for and demonstrated evidence of low frequency synchronization of activity in the pedunculopontine nucleus of a patient with Parkinson's disease that increased after treatment with dopamine and which might be mimicked by local deep brain stimulation at low frequency.

AB - The pedunculopontine nucleus has recently been introduced as a new therapeutic target for deep brain stimulation in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus. Therefore, we looked for and demonstrated evidence of low frequency synchronization of activity in the pedunculopontine nucleus of a patient with Parkinson's disease that increased after treatment with dopamine and which might be mimicked by local deep brain stimulation at low frequency.

UR - https://www.scopus.com/pages/publications/40349100364

U2 - 10.1097/WNR.0b013e3282f2e2d1

DO - 10.1097/WNR.0b013e3282f2e2d1

M3 - Article

SN - 0959-4965

VL - 19

SP - 59

EP - 62

JO - NeuroReport

JF - NeuroReport

IS - 1

ER -