Localised oral amyloidosis in the context of oral epithelial dysplasia: Literature review and report of two cases

Marianne L. Dobson (Lead / Corresponding author), Alison L. Wright, Sharon J. White, Michaelina Macluskey

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Abstract

Amyloidosis is a group of rare progressive diseases that occur as a result of abnormal protein folding and aggregation. Systemic amyloidosis is a serious disease with high mortality, and prompt diagnosis is key to improving prognosis. Conversely, localised amyloidosis does not reduce life expectancy and can often be treated with simple surgical excision. Amyloid deposits can be found in the oral cavity, usually in the context of systemic amyloidosis. We present two cases of localised oral acquired immunoglobulin light chain (AL) amyloidosis that were detected in oral biopsies taken for the management of oral epithelial dysplasia (OED). Both patients underwent thorough multisystem investigations by haematology in conjunction with the NHS National Amyloidosis Centre (NAC) in order to exclude systemic amyloidosis and confirm the diagnosis. Localised oral amyloidosis is rare, and to our knowledge, localised oral AL amyloidosis has not been reported in the context of OED before. We discuss important learning points from these cases as well as hypothesising on the pathophysiology involved.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalOral Surgery
Volume15
Issue number3
Early online date25 Mar 2021
DOIs
Publication statusPublished - Aug 2022

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery

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