Location, location, location: identifying the neighborhoods of LPS signaling

Colin Watts

doi:10.1038/ni0408-343

Location, location, location: identifying the neighborhoods of LPS signaling

Colin Watts

Research output: Contribution to journal › Editorial › peer-review

27 Citations (Scopus)

Abstract

TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitovc and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.

Original language	English
Pages (from-to)	343-345
Number of pages	3
Journal	Nature Immunology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/ni0408-343
Publication status	Published - Apr 2008

Keywords

RECEPTOR
TRIF

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10.1038/ni0408-343

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title = "Location, location, location: identifying the neighborhoods of LPS signaling",

abstract = "TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitovc and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.",

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AB - TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitovc and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.

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KW - TRIF

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DO - 10.1038/ni0408-343

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JO - Nature Immunology

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Location, location, location: identifying the neighborhoods of LPS signaling

Abstract

Keywords

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