Location, location, location: identifying the neighborhoods of LPS signaling

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    Abstract

    TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitovc and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.

    Original languageEnglish
    Pages (from-to)343-345
    Number of pages3
    JournalNature Immunology
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - Apr 2008

    Keywords

    • RECEPTOR
    • TRIF

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