Long-term follow-up of patients undergoing laparoscopic surgery for phaeochromocytoma

Patrick J. O'Dwyer (Lead / Corresponding author), Cindy Chew, Samer Zino, Michael G. Serpell

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3 Citations (Scopus)
39 Downloads (Pure)

Abstract

INTRODUCTION: Phaeochromocytomas are rare tumours with a recurrence after open surgery ranging between 6-23 per cent. Long-term follow-up studies after laparoscopic surgery for phaeochromocytoma are lacking. The aim of this study was to look at the long-term oncological outcome of a consecutive series of patients from a single centre undergoing laparoscopic surgery for a phaeochromocytoma. METHODS: Demographic data on all patients with an adrenal tumour or paraganglioma were prospectively kept on a database between September 1999 and December 2017. Electronic hospital records, including imaging from a national linked archiving and communication system, were reviewed for patients with a phaeochromocytoma in November 2021. RESULTS: During the study interval 135 patients with a phaeochromocytoma were operated on in the unit, of which 118 (87.4 per cent) were attempted laparoscopically. Five (4.2 per cent) were converted to open surgery, whereas 117 had a potentially curative operation. There was no peri- or postoperative mortality. At a median follow-up of 10 (interquartile range 6-12.9) years, only 3 (2.6 per cent) patients died from metastatic phaeochromocytoma. One further patient developed lymph node metastases, which were removed at open surgery. No patient had a local recurrence and the only significant predictor of recurrence was the presence of lymph node metastases (P < 0.001). Two patients developed a contralateral adrenal phaeochromocytoma, while one of these also had a paraganglioma. The Kaplan-Meier estimate of phaeochromocytoma-free survival was 96 per cent (95 per cent c.i. 92.2 to 98.8) at 5 years and 92 per cent (95 per cent c.i. 86.7 to 97.3) at 10 years. CONCLUSION: This study demonstrates that long-term oncological outcomes of laparoscopic surgery for patients with a phaeochromocytoma are at least as good as that with an open operation.

Original languageEnglish
Article numberzrac076
Number of pages5
JournalBJS open
Volume6
Issue number3
Early online date2 May 2022
DOIs
Publication statusPublished - 27 Jun 2022

Keywords

  • Adrenal Gland Neoplasms/surgery
  • Follow-Up Studies
  • Humans
  • Laparoscopy/adverse effects
  • Lymphatic Metastasis
  • Paraganglioma/surgery
  • Pheochromocytoma/surgery

ASJC Scopus subject areas

  • General Medicine

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