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Abstract
Background: Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth.
Objectives: To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty.
Results: Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited.
Conclusions: Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.
Original language | English |
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Pages (from-to) | 509-525 |
Number of pages | 17 |
Journal | Neuroscience and Biobehavioral Reviews |
Volume | 120 |
Early online date | 17 Oct 2020 |
DOIs | |
Publication status | Published - Jan 2021 |
Keywords
- Attention deficit/hyperactivity disorder (ADHD)
- methylphenidate
- stimulants
- height
- weight
- growth
- puberty
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience
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Dive into the research topics of 'Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis'. Together they form a unique fingerprint.Projects
- 1 Finished
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Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) (joint with 13 other partners)
Coghill, D. (Investigator) & Matthews, K. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/01/11 → 30/06/16
Project: Research