Skip to main navigation Skip to search Skip to main content

Longitudinal and cross-sectional associations of myocardial stress markers with kidney function and chronic kidney disease in the BiomarCaRE project

  • Jie Sheng Lin
  • , Tanja Zeller
  • , Wolfgang Koenig
  • , Pekka Jousilahti
  • , Frank Kee
  • , Licia Iacoviello
  • , Hugh Tunstall-Pedoe
  • , Stefan Söderberg
  • , Giancarlo Cesana
  • , Luigi Palmieri
  • , Veikko Salomaa
  • , Julia de Man Lapidoth
  • , Roberto De Ponti
  • , Chiara Donfrancesco
  • , Thiess Lorenz
  • , Kari Kuulasmaa
  • , Stefan Blankenberg
  • , Annette Peters
  • , Barbara Thorand (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

3 Downloads (Pure)

Abstract

Given the complex relationship between cardiovascular disease (CVD) and chronic kidney disease (CKD), CVD-related markers may serve as CKD biomarkers. We examined associations of three major CVD-markers [mid-regional pro-adrenomedullin (MR-proADM), MR-pro-atrial natriuretic peptide (MR-proANP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP)] with CKD. Cross-sectional analyses included up to 61,830 participants, and longitudinal analyses (NT-proBNP only) 4205 individuals. Kidney function was assessed by estimated glomerular filtration rate (eGFR) using creatinine, cystatin C, or both (eGFRcr-cys). Markers were categorized into four groups. Cross-sectional analyses found that higher levels of all three markers were consistently associated with lower eGFR and higher CKD prevalence. For example, per 1 standard deviation (SD) increase in log-transformed NT-proBNP, corresponding to a 2.71-fold increase in the original concentration, was associated with -2.35 (-2.49, -2.21) ml/min/1.73m2 lower eGFRcr-cys, and the highest NT-proBNP group had a 5.72-fold higher odds of CKDcr-cys (eGFRcr-cys < 60 ml/min/1.73m2) compared with the lowest. Associations with eGFR were stronger among participants with CVD and diabetes. In longitudinal analyses, participants with higher baseline NT-proBNP had faster declines in eGFR, with a 10-year decline of -1.37 (-1.77, -0.98) ml/min/1.73m2 eGFRcr-cys per 1 SD increase, and higher CKD incidence. These findings suggest MR-proADM, MR-proANP, and NT-proBNP as CKD biomarkers.

Original languageEnglish
Article number7488
Number of pages14
JournalScientific Reports
Volume16
DOIs
Publication statusPublished - 23 Feb 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Chronic kidney disease
  • Kidney function
  • MR-proADM
  • MR-proANP
  • NT-p
  • roBNP

ASJC Scopus subject areas

  • General

Access to Document

  • Final Published Version

    Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

    Final published version, 3.66 MBLicence: CC BY

Other files and links

    Fingerprint

    Dive into the research topics of 'Longitudinal and cross-sectional associations of myocardial stress markers with kidney function and chronic kidney disease in the BiomarCaRE project'. Together they form a unique fingerprint.
    View full fingerprint

    Cite this