Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

Keyphrases

• Gain-of-function mutation 100%
• Cutaneous Squamous Cell Carcinoma (cSCC) 100%
• Lung Squamous Cell Carcinoma 100%
• Epithelial Malignancies 100%
• Notch Receptors 100%
• In Cancer 50%
• Neighboring Cells 50%
• Microenvironment 50%
• Notch Pathway 50%
• Tumor Suppressor 50%
• Human Cancer 50%
• Metazoan 50%
• Cell-based 50%
• T Cells 50%
• Frameshift mutation 50%
• Functional Domain 50%
• Nonsense mutation 50%
• TP53 mutation 50%
• Truncation 50%
• Cancer Progression 50%
• Squamous Cell Carcinoma (SqCC) 50%
• Aberrations 50%
• Lymphoma Cells 50%
• Human Malignancies 50%
• Leukemia-lymphoma 50%
• Context Dependence 50%
• Somatic Aberrations 50%
• NOTCH2 mutation 50%
• NOTCH1 mutation 50%
• B-CLL 50%
• Notch1 50%
• T-cell Acute Lymphoblastic Leukemia (T-ALL) 50%
• Bifunctional 50%
• Developmental Patterning 50%
• Lineage Selection 50%
• Targeted Inhibition 50%

Medicine and Dentistry

• Cancer 100%
• Loss of Function Mutation 100%
• Skin Carcinoma 100%
• Notch Receptor 100%
• Squamous Cell Lung Carcinoma 100%
• Notch 66%
• Malignant Neoplasm 33%
• Carcinogenesis 33%
• Receptor 33%
• T Cell 33%
• Frameshift Mutation 33%
• Cancer Growth 33%
• Squamous Cell Carcinoma 33%
• Somatics 33%
• Lymphoid Leukemia 33%
• Gain of Function Mutation 33%
• B-Cell Chronic Lymphocytic Leukemia 33%
• Nonsense Mutation 33%
• Tumor Suppressor Protein 33%

Biochemistry, Genetics and Molecular Biology

• Notch 100%
• Loss of Function Mutation 100%
• Notch Proteins 100%
• Carcinogenesis 50%
• Tumor Suppressor Protein 50%
• T Cell 50%
• B Cell 50%
• Frameshift Mutation 50%
• Nonsense Mutation 50%
• Gain of Function Mutation 50%