Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery

J. J. F. Belch; G. D. Lowe; J. G. Pollock; C. D. Forbes; C. R. Prentice

Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery

J. J. F. Belch
, G. D. Lowe
, J. G. Pollock
, C. D. Forbes
, C. R. Prentice

Research output: Contribution to journal › Article › peer-review

Abstract

In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2,500 u pre-operatively then 5,000 u 12-hourly for 7 days) and 25 control patients received saline injections. All patients received a routine dose of intravenous sodium heparin intra-operatively. The trial was terminated because of excess bleeding complications in patients receiving subcutaneous heparin (8 vs. 1, p less than 0.05). Deep vein thrombosis occurred in 6 control patients and 2 patients on heparin (p less than 0.05). In this group of patients undergoing major vascular surgery the risk of bleeding due to heparin outweighed the potential benefit of thrombotic prophylaxis.

Original language	English
Pages (from-to)	1429-33
Number of pages	5
Journal	Thrombosis and Haemostasis
Volume	42
Issue number	5
Publication status	Published - 1980

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Belch, J. J. F., Lowe, G. D., Pollock, J. G., Forbes, C. D., & Prentice, C. R. (1980). Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery. Thrombosis and Haemostasis, 42(5), 1429-33. http://www.scopus.com/record/display.url?eid=2-s2.0-0018890760&origin=resultslist&sort=plf-f&src=s&st1=Low+dose+heparin+in+the+prevention+of+deep-vein+thrombosis&nlo=&nlr=&nls=&sid=8C06BDA0E31EF3D63360298C7541F619.FZg2ODcJC9ArCe8WOZPvA%3a100&sot=b&sdt=cl&cluster=scopubyr%2c%221980%22%2ct&sl=73&s=TITLE-ABS-KEY%28Low+dose+heparin+in+the+prevention+of+deep-vein+thrombosis%29&relpos=12&relpos=12&searchTerm=TITLE-ABS-KEY%28Low+dose+heparin+in+the+prevention+of+deep-vein+thrombosis%29+AND+%28+LIMIT-TO%28PUBYEAR%2C1980%29+%29+#

@article{180627911727449ea7813ecf9552254f,

title = "Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery",

abstract = "In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2,500 u pre-operatively then 5,000 u 12-hourly for 7 days) and 25 control patients received saline injections. All patients received a routine dose of intravenous sodium heparin intra-operatively. The trial was terminated because of excess bleeding complications in patients receiving subcutaneous heparin (8 vs. 1, p less than 0.05). Deep vein thrombosis occurred in 6 control patients and 2 patients on heparin (p less than 0.05). In this group of patients undergoing major vascular surgery the risk of bleeding due to heparin outweighed the potential benefit of thrombotic prophylaxis.",

author = "Belch, \{J. J. F.\} and Lowe, \{G. D.\} and Pollock, \{J. G.\} and Forbes, \{C. D.\} and Prentice, \{C. R.\}",

year = "1980",

language = "English",

volume = "42",

pages = "1429--33",

journal = "Thrombosis and Haemostasis",

issn = "0340-6245",

publisher = "Georg Thieme Verlag",

number = "5",

}

Belch, JJF, Lowe, GD, Pollock, JG, Forbes, CD & Prentice, CR 1980, 'Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery', Thrombosis and Haemostasis, vol. 42, no. 5, pp. 1429-33. <http://www.scopus.com/record/display.url?eid=2-s2.0-0018890760&origin=resultslist&sort=plf-f&src=s&st1=Low+dose+heparin+in+the+prevention+of+deep-vein+thrombosis&nlo=&nlr=&nls=&sid=8C06BDA0E31EF3D63360298C7541F619.FZg2ODcJC9ArCe8WOZPvA%3a100&sot=b&sdt=cl&cluster=scopubyr%2c%221980%22%2ct&sl=73&s=TITLE-ABS-KEY%28Low+dose+heparin+in+the+prevention+of+deep-vein+thrombosis%29&relpos=12&relpos=12&searchTerm=TITLE-ABS-KEY%28Low+dose+heparin+in+the+prevention+of+deep-vein+thrombosis%29+AND+%28+LIMIT-TO%28PUBYEAR%2C1980%29+%29+#>

TY - JOUR

T1 - Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery

AU - Belch, J. J. F.

AU - Lowe, G. D.

AU - Pollock, J. G.

AU - Forbes, C. D.

AU - Prentice, C. R.

PY - 1980

Y1 - 1980

N2 - In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2,500 u pre-operatively then 5,000 u 12-hourly for 7 days) and 25 control patients received saline injections. All patients received a routine dose of intravenous sodium heparin intra-operatively. The trial was terminated because of excess bleeding complications in patients receiving subcutaneous heparin (8 vs. 1, p less than 0.05). Deep vein thrombosis occurred in 6 control patients and 2 patients on heparin (p less than 0.05). In this group of patients undergoing major vascular surgery the risk of bleeding due to heparin outweighed the potential benefit of thrombotic prophylaxis.

AB - In a randomised double-blind controlled trial 24 patients undergoing elective aortic bifurcation graft surgery received subcutaneous calcium heparin (2,500 u pre-operatively then 5,000 u 12-hourly for 7 days) and 25 control patients received saline injections. All patients received a routine dose of intravenous sodium heparin intra-operatively. The trial was terminated because of excess bleeding complications in patients receiving subcutaneous heparin (8 vs. 1, p less than 0.05). Deep vein thrombosis occurred in 6 control patients and 2 patients on heparin (p less than 0.05). In this group of patients undergoing major vascular surgery the risk of bleeding due to heparin outweighed the potential benefit of thrombotic prophylaxis.

M3 - Article

C2 - 7368149

SN - 0340-6245

VL - 42

SP - 1429

EP - 1433

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

IS - 5

ER -

Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery

Abstract

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