Low Dose Responses of Bone Marrow to X-Rays In Vivo

Nikolay A. Zyuzikov, Philip J. Coates, Sally A. Lorimore, Eric G. Wright

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Radiation risk at low doses is determined by linear extrapolation from high dose epidemiological data. In the last decade many non-targeted effects have been reported which may be relevant to low dose risk determination. To investigate cell responses at such low doses we used bone marrow cells of mice. We have not observed non-targeted effects long- or short-term post irradiation. Exposure below 50-100 mGy provides no evidence of a dose response for apoptotic signaling, bystander effects and low responses for p53 and p21 induction with significant individual variability. There is also no evidence for long-term chromosomal instability in the bone marrow at doses below 1 Gy. The data also demonstrate unexpected thresholds above which dose-dependent damage signaling is observed and the chromosomal instability phenotype is induced. The data are consistent with low dose X-irradiation being less damaging than would be expected from the LNT paradigm.

    Original languageEnglish
    Title of host publicationRadiobiology and environmental security
    EditorsCE Mothersill, V Korogodina, CB Seymour
    Place of PublicationDordrecht
    PublisherSpringer
    Pages141-151
    Number of pages11
    ISBN (Print)978-94-007-1938-5
    DOIs
    Publication statusPublished - 2012
    EventNATO Advanced Research Workshop on Radiological Issues Pertaining to Environmental Security and Ecoterrorism - Alushta, Ukraine
    Duration: 9 Oct 201014 Oct 2010

    Conference

    ConferenceNATO Advanced Research Workshop on Radiological Issues Pertaining to Environmental Security and Ecoterrorism
    CountryUkraine
    CityAlushta
    Period9/10/1014/10/10

    Cite this

    Zyuzikov, N. A., Coates, P. J., Lorimore, S. A., & Wright, E. G. (2012). Low Dose Responses of Bone Marrow to X-Rays In Vivo. In CE. Mothersill, V. Korogodina, & CB. Seymour (Eds.), Radiobiology and environmental security (pp. 141-151). Springer . https://doi.org/10.1007/978-94-007-1939-2_13