Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome

Vance A. Spence, Gwen Kennedy, Jill J. F. Belch, Alexander Hill, Faisel Khan

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Some of the symptoms reported by people with CFS (chronic fatigue syndrome) are associated with various cardiovascular phenomena. Markers of cardiovascular risk, including inflammation and oxidative stress, have been demonstrated in some patients with CFS, but little is known about the relationship between these and prognostic indicators of cardiovascular risk in this patient group. In the present study, we investigated the relationship between inflammation and oxidative stress and augmentation index, a measure of arterial stiffness, in 41 well-characterized patients with CFS and in 30 healthy subjects. Alx@75 (augmentation index normalized for a heart rate of 75 beats/min) was significantly greater in patients with CFS than in control subjects (22.5 +/- 1.7 compared with 13.3 +/- 2.3 % respectively; P = 0.002). Patients with CFS also had significantly increased levels of CRP (C-reactive protein) (2.58 +/- 2.91 compared with 1.07 +/- 2.16 mu g/ml respectively; P < 0.01) and 8-iso-prostaglandin F-2 alpha isoprostanes (470.7 +/- 250.9 compared with 331.1 +/- 97.6 pg/ml respectively; P < 0.005). In patients with CFS, Alx@75 correlated significantly with logCRP (r = 0.507, P = 0.001), isoprostanes (r = 0.366, P = 0.026), oxidized LDL (low-density lipoprotein) (r = 0.333, P = 0.039) and systolic blood pressure (r = 0.371, P = 0.0 17). In a stepwise multiple regression model, including systolic and diastolic blood pressure, body mass index, CRP, tumour necrosis factor-a, interleukin-1, oxidized LDL, high-density lipoprotein-cholesterol levels, isoprostanes, age and gender, Alx@75 was independently associated with logCRP (beta=0.385, P = 0.006), age (beta = 0.363, P = 0.022) and female gender (beta = 0.302, P = 0.03) in patients with CFS. The combination of increased arterial wave reflection, inflammation and oxidative stress may result in an increased risk of future cardiovascular events. Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group.

    Original languageEnglish
    Pages (from-to)561-566
    Number of pages6
    JournalClinical and Translational Science
    Volume114
    Issue number7-8
    DOIs
    Publication statusPublished - Apr 2008

    Keywords

    • arterial stiffness
    • augmentation index
    • cardiovascular risk
    • chronic fatigue syndrome
    • inflammation
    • pulse wave analysis
    • C-REACTIVE PROTEIN
    • CORONARY-HEART-DISEASE
    • OXIDATIVE STRESS
    • CARDIOVASCULAR EVENTS
    • PHYSICAL-ACTIVITY
    • NEUTROPHIL APOPTOSIS
    • CONSENSUS DOCUMENT
    • AUGMENTATION INDEX
    • STIFFNESS
    • MARKERS

    Cite this

    @article{ff0c41a2fb104843a545bc9e6c7d92a1,
    title = "Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome",
    abstract = "Some of the symptoms reported by people with CFS (chronic fatigue syndrome) are associated with various cardiovascular phenomena. Markers of cardiovascular risk, including inflammation and oxidative stress, have been demonstrated in some patients with CFS, but little is known about the relationship between these and prognostic indicators of cardiovascular risk in this patient group. In the present study, we investigated the relationship between inflammation and oxidative stress and augmentation index, a measure of arterial stiffness, in 41 well-characterized patients with CFS and in 30 healthy subjects. Alx@75 (augmentation index normalized for a heart rate of 75 beats/min) was significantly greater in patients with CFS than in control subjects (22.5 +/- 1.7 compared with 13.3 +/- 2.3 {\%} respectively; P = 0.002). Patients with CFS also had significantly increased levels of CRP (C-reactive protein) (2.58 +/- 2.91 compared with 1.07 +/- 2.16 mu g/ml respectively; P < 0.01) and 8-iso-prostaglandin F-2 alpha isoprostanes (470.7 +/- 250.9 compared with 331.1 +/- 97.6 pg/ml respectively; P < 0.005). In patients with CFS, Alx@75 correlated significantly with logCRP (r = 0.507, P = 0.001), isoprostanes (r = 0.366, P = 0.026), oxidized LDL (low-density lipoprotein) (r = 0.333, P = 0.039) and systolic blood pressure (r = 0.371, P = 0.0 17). In a stepwise multiple regression model, including systolic and diastolic blood pressure, body mass index, CRP, tumour necrosis factor-a, interleukin-1, oxidized LDL, high-density lipoprotein-cholesterol levels, isoprostanes, age and gender, Alx@75 was independently associated with logCRP (beta=0.385, P = 0.006), age (beta = 0.363, P = 0.022) and female gender (beta = 0.302, P = 0.03) in patients with CFS. The combination of increased arterial wave reflection, inflammation and oxidative stress may result in an increased risk of future cardiovascular events. Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group.",
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    Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome. / Spence, Vance A.; Kennedy, Gwen; Belch, Jill J. F.; Hill, Alexander; Khan, Faisel.

    In: Clinical and Translational Science, Vol. 114, No. 7-8, 04.2008, p. 561-566.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome

    AU - Spence, Vance A.

    AU - Kennedy, Gwen

    AU - Belch, Jill J. F.

    AU - Hill, Alexander

    AU - Khan, Faisel

    PY - 2008/4

    Y1 - 2008/4

    N2 - Some of the symptoms reported by people with CFS (chronic fatigue syndrome) are associated with various cardiovascular phenomena. Markers of cardiovascular risk, including inflammation and oxidative stress, have been demonstrated in some patients with CFS, but little is known about the relationship between these and prognostic indicators of cardiovascular risk in this patient group. In the present study, we investigated the relationship between inflammation and oxidative stress and augmentation index, a measure of arterial stiffness, in 41 well-characterized patients with CFS and in 30 healthy subjects. Alx@75 (augmentation index normalized for a heart rate of 75 beats/min) was significantly greater in patients with CFS than in control subjects (22.5 +/- 1.7 compared with 13.3 +/- 2.3 % respectively; P = 0.002). Patients with CFS also had significantly increased levels of CRP (C-reactive protein) (2.58 +/- 2.91 compared with 1.07 +/- 2.16 mu g/ml respectively; P < 0.01) and 8-iso-prostaglandin F-2 alpha isoprostanes (470.7 +/- 250.9 compared with 331.1 +/- 97.6 pg/ml respectively; P < 0.005). In patients with CFS, Alx@75 correlated significantly with logCRP (r = 0.507, P = 0.001), isoprostanes (r = 0.366, P = 0.026), oxidized LDL (low-density lipoprotein) (r = 0.333, P = 0.039) and systolic blood pressure (r = 0.371, P = 0.0 17). In a stepwise multiple regression model, including systolic and diastolic blood pressure, body mass index, CRP, tumour necrosis factor-a, interleukin-1, oxidized LDL, high-density lipoprotein-cholesterol levels, isoprostanes, age and gender, Alx@75 was independently associated with logCRP (beta=0.385, P = 0.006), age (beta = 0.363, P = 0.022) and female gender (beta = 0.302, P = 0.03) in patients with CFS. The combination of increased arterial wave reflection, inflammation and oxidative stress may result in an increased risk of future cardiovascular events. Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group.

    AB - Some of the symptoms reported by people with CFS (chronic fatigue syndrome) are associated with various cardiovascular phenomena. Markers of cardiovascular risk, including inflammation and oxidative stress, have been demonstrated in some patients with CFS, but little is known about the relationship between these and prognostic indicators of cardiovascular risk in this patient group. In the present study, we investigated the relationship between inflammation and oxidative stress and augmentation index, a measure of arterial stiffness, in 41 well-characterized patients with CFS and in 30 healthy subjects. Alx@75 (augmentation index normalized for a heart rate of 75 beats/min) was significantly greater in patients with CFS than in control subjects (22.5 +/- 1.7 compared with 13.3 +/- 2.3 % respectively; P = 0.002). Patients with CFS also had significantly increased levels of CRP (C-reactive protein) (2.58 +/- 2.91 compared with 1.07 +/- 2.16 mu g/ml respectively; P < 0.01) and 8-iso-prostaglandin F-2 alpha isoprostanes (470.7 +/- 250.9 compared with 331.1 +/- 97.6 pg/ml respectively; P < 0.005). In patients with CFS, Alx@75 correlated significantly with logCRP (r = 0.507, P = 0.001), isoprostanes (r = 0.366, P = 0.026), oxidized LDL (low-density lipoprotein) (r = 0.333, P = 0.039) and systolic blood pressure (r = 0.371, P = 0.0 17). In a stepwise multiple regression model, including systolic and diastolic blood pressure, body mass index, CRP, tumour necrosis factor-a, interleukin-1, oxidized LDL, high-density lipoprotein-cholesterol levels, isoprostanes, age and gender, Alx@75 was independently associated with logCRP (beta=0.385, P = 0.006), age (beta = 0.363, P = 0.022) and female gender (beta = 0.302, P = 0.03) in patients with CFS. The combination of increased arterial wave reflection, inflammation and oxidative stress may result in an increased risk of future cardiovascular events. Assessment of arterial wave reflection might be useful for determining cardiovascular risk in this patient group.

    KW - arterial stiffness

    KW - augmentation index

    KW - cardiovascular risk

    KW - chronic fatigue syndrome

    KW - inflammation

    KW - pulse wave analysis

    KW - C-REACTIVE PROTEIN

    KW - CORONARY-HEART-DISEASE

    KW - OXIDATIVE STRESS

    KW - CARDIOVASCULAR EVENTS

    KW - PHYSICAL-ACTIVITY

    KW - NEUTROPHIL APOPTOSIS

    KW - CONSENSUS DOCUMENT

    KW - AUGMENTATION INDEX

    KW - STIFFNESS

    KW - MARKERS

    U2 - 10.1042/CS20070274

    DO - 10.1042/CS20070274

    M3 - Article

    VL - 114

    SP - 561

    EP - 566

    JO - Clinical and Translational Science

    JF - Clinical and Translational Science

    SN - 1752-8054

    IS - 7-8

    ER -