Lysosomal and vacuolar sorting: Not so different after all!

Carine De Marcos Lousa (Lead / Corresponding author), Jurgen Denecke (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Soluble hydrolases represent the main proteins of lysosomes and vacuoles and are essential to sustain the lytic properties of these organelles typical for the eukaryotic organisms. The sorting of these proteins from ER residents and secreted proteins is controlled by highly specific receptors to avoid mislocalization and subsequent cellular damage. After binding their soluble cargo in the early stage of the secretory pathway, receptors rely on their own sorting signals to reach their target organelles for ligand delivery, and to recycle back for a new round of cargo recognition. Although signals in cargo and receptor molecules have been studied in human, yeast and plant model systems, common denominators and specific examples of diversification have not been systematically explored. This review aims to fill this niche by comparing the structure and the function of lysosomal/vacuolar sorting receptors (VSRs) from these three organisms.

Original languageEnglish
Pages (from-to)891-897
Number of pages7
JournalBiochemical Society Transactions
Issue number3
Early online date9 Jun 2016
Publication statusPublished - Jun 2016


  • Endosomal sorting
  • Lysosomes
  • Receptors
  • Trafficking
  • Vacuole

ASJC Scopus subject areas

  • Biochemistry


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