Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- And 28-membered rings

Simon Carrington; Ian S. Blagbrough; Alan H. Fairlamb

doi:10.1039/a806688d

Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- And 28-membered rings

Simon Carrington, Ian S. Blagbrough (Lead / Corresponding author), Alan H. Fairlamb

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Novel 23-, 24- and 28-membered cyclic polyamine amides (cinnamamides) have been prepared by closure of diphenyl ethers; functionalized conjugates of spermidine and spermine underwent intramolecular aromatic nucleophilic substitution to afford nitro-substituted analogues of cadabicine class (24-membered polyamine lactam) alkaloids.

Original language	English
Pages (from-to)	2335-2336
Number of pages	2
Journal	Chemical Communications
Issue number	21
DOIs	https://doi.org/10.1039/a806688d
Publication status	Published - 7 Nov 1998

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/a806688d

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title = "Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- And 28-membered rings",

abstract = "Novel 23-, 24- and 28-membered cyclic polyamine amides (cinnamamides) have been prepared by closure of diphenyl ethers; functionalized conjugates of spermidine and spermine underwent intramolecular aromatic nucleophilic substitution to afford nitro-substituted analogues of cadabicine class (24-membered polyamine lactam) alkaloids.",

author = "Simon Carrington and Blagbrough, {Ian S.} and Fairlamb, {Alan H.}",

year = "1998",

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doi = "10.1039/a806688d",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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AU - Carrington, Simon

AU - Blagbrough, Ian S.

AU - Fairlamb, Alan H.

PY - 1998/11/7

Y1 - 1998/11/7

N2 - Novel 23-, 24- and 28-membered cyclic polyamine amides (cinnamamides) have been prepared by closure of diphenyl ethers; functionalized conjugates of spermidine and spermine underwent intramolecular aromatic nucleophilic substitution to afford nitro-substituted analogues of cadabicine class (24-membered polyamine lactam) alkaloids.

AB - Novel 23-, 24- and 28-membered cyclic polyamine amides (cinnamamides) have been prepared by closure of diphenyl ethers; functionalized conjugates of spermidine and spermine underwent intramolecular aromatic nucleophilic substitution to afford nitro-substituted analogues of cadabicine class (24-membered polyamine lactam) alkaloids.

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U2 - 10.1039/a806688d

DO - 10.1039/a806688d

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SN - 1359-7345

SP - 2335

EP - 2336

JO - Chemical Communications

JF - Chemical Communications

IS - 21

ER -

Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- And 28-membered rings

Abstract

ASJC Scopus subject areas

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