Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Catherine  Ropert; Ludmila R. P.  Ferreira; M A S  Campos; D O  Procopio; L R  Travassos; Michael A. J.  Ferguson; L F L  Reis; M M  Teixeira; I C  Almeida; R T  Gazzinelli

doi:10.1016/S1286-4579(02)01609-X

Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Catherine Ropert, Ludmila R. P. Ferreira, M A S Campos, D O Procopio, L R Travassos, Michael A. J. Ferguson, L F L Reis, M M Teixeira, I C Almeida, R T Gazzinelli

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68 Citations (Scopus)

Abstract

Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

Original language	English
Pages (from-to)	1015-1025
Number of pages	11
Journal	Microbes and Infection
Volume	4
Issue number	9
DOIs	https://doi.org/10.1016/S1286-4579(02)01609-X
Publication status	Published - Jul 2002

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Ropert, C., Ferreira, L. R. P., Campos, M. A. S., Procopio, D. O., Travassos, L. R., Ferguson, M. A. J., Reis, L. F. L., Teixeira, M. M., Almeida, I. C., & Gazzinelli, R. T. (2002). Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes. Microbes and Infection, 4(9), 1015-1025. https://doi.org/10.1016/S1286-4579(02)01609-X

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title = "Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes",

abstract = "Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.",

author = "Catherine Ropert and Ferreira, {Ludmila R. P.} and Campos, {M A S} and Procopio, {D O} and Travassos, {L R} and Ferguson, {Michael A. J.} and Reis, {L F L} and Teixeira, {M M} and Almeida, {I C} and Gazzinelli, {R T}",

year = "2002",

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doi = "10.1016/S1286-4579(02)01609-X",

language = "English",

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Ropert, C, Ferreira, LRP, Campos, MAS, Procopio, DO, Travassos, LR, Ferguson, MAJ, Reis, LFL, Teixeira, MM, Almeida, IC & Gazzinelli, RT 2002, 'Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes', Microbes and Infection, vol. 4, no. 9, pp. 1015-1025. https://doi.org/10.1016/S1286-4579(02)01609-X

TY - JOUR

T1 - Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

AU - Ropert, Catherine

AU - Ferreira, Ludmila R. P.

AU - Campos, M A S

AU - Procopio, D O

AU - Travassos, L R

AU - Ferguson, Michael A. J.

AU - Reis, L F L

AU - Teixeira, M M

AU - Almeida, I C

AU - Gazzinelli, R T

PY - 2002/7

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N2 - Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

AB - Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

U2 - 10.1016/S1286-4579(02)01609-X

DO - 10.1016/S1286-4579(02)01609-X

M3 - Article

SN - 1286-4579

VL - 4

SP - 1015

EP - 1025

JO - Microbes and Infection

JF - Microbes and Infection

IS - 9

ER -

Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Abstract

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