Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes

Catherine Ropert, Ludmila R. P. Ferreira, M A S Campos, D O Procopio, L R Travassos, Michael A. J. Ferguson, L F L Reis, M M Teixeira, I C Almeida, R T Gazzinelli

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    Abstract

    Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

    Original languageEnglish
    Pages (from-to)1015-1025
    Number of pages11
    JournalMicrobes and Infection
    Volume4
    Issue number9
    DOIs
    Publication statusPublished - Jul 2002

    Cite this

    Ropert, C., Ferreira, L. R. P., Campos, M. A. S., Procopio, D. O., Travassos, L. R., Ferguson, M. A. J., Reis, L. F. L., Teixeira, M. M., Almeida, I. C., & Gazzinelli, R. T. (2002). Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes. Microbes and Infection, 4(9), 1015-1025. https://doi.org/10.1016/S1286-4579(02)01609-X