Macropinocytosis

Joel A. Swanson, Colin Watts

    Research output: Contribution to journalReview articlepeer-review

    704 Citations (Scopus)

    Abstract

    Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute macromolecules. This route may facilitate MHC-class-II-restricted antigen presentation by dendritic cells. Because the ruffling that leads to macropinocytosis is regulated, it has been exploited by some pathogenic bacteria as a novel route for entry into cells.

    Original languageEnglish
    Pages (from-to)424-428
    Number of pages5
    JournalTrends in Cell Biology
    Volume5
    Issue number11
    DOIs
    Publication statusPublished - Nov 1995

    ASJC Scopus subject areas

    • Cell Biology

    Fingerprint

    Dive into the research topics of 'Macropinocytosis'. Together they form a unique fingerprint.

    Cite this