Macropinocytosis

Joel A. Swanson; Colin Watts

doi:10.1016/S0962-8924(00)89101-1

Macropinocytosis

Joel A. Swanson
, Colin Watts

Research output: Contribution to journal › Review article › peer-review

745 Citations (Scopus)

Abstract

Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute macromolecules. This route may facilitate MHC-class-II-restricted antigen presentation by dendritic cells. Because the ruffling that leads to macropinocytosis is regulated, it has been exploited by some pathogenic bacteria as a novel route for entry into cells.

Original language	English
Pages (from-to)	424-428
Number of pages	5
Journal	Trends in Cell Biology
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/S0962-8924(00)89101-1
Publication status	Published - Nov 1995

ASJC Scopus subject areas

Cell Biology

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10.1016/S0962-8924(00)89101-1

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title = "Macropinocytosis",

abstract = "Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute macromolecules. This route may facilitate MHC-class-II-restricted antigen presentation by dendritic cells. Because the ruffling that leads to macropinocytosis is regulated, it has been exploited by some pathogenic bacteria as a novel route for entry into cells.",

author = "Swanson, \{Joel A.\} and Colin Watts",

year = "1995",

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journal = "Trends in Cell Biology",

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T1 - Macropinocytosis

AU - Swanson, Joel A.

AU - Watts, Colin

PY - 1995/11

Y1 - 1995/11

N2 - Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute macromolecules. This route may facilitate MHC-class-II-restricted antigen presentation by dendritic cells. Because the ruffling that leads to macropinocytosis is regulated, it has been exploited by some pathogenic bacteria as a novel route for entry into cells.

AB - Macropinocytosis is a form of endocytosis that accompanies cell surface ruffling. It is distinct in many ways from the better characterized micropinocytosis, which includes clathrin-coated vesicle endocytosis and small uncoated vesicles. Because macropinosomes are relatively large, they provide an efficient route for non-selective endocytosis of solute macromolecules. This route may facilitate MHC-class-II-restricted antigen presentation by dendritic cells. Because the ruffling that leads to macropinocytosis is regulated, it has been exploited by some pathogenic bacteria as a novel route for entry into cells.

UR - https://www.scopus.com/pages/publications/0028790788

U2 - 10.1016/S0962-8924(00)89101-1

DO - 10.1016/S0962-8924(00)89101-1

M3 - Review article

AN - SCOPUS:0028790788

SN - 0962-8924

VL - 5

SP - 424

EP - 428

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 11

ER -

Macropinocytosis

Abstract

ASJC Scopus subject areas

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