Macrovascular disease in systemic sclerosis: the tip of an iceberg?

J. J. F. Belch; S. McSwiggan; C. Lau

doi:10.1093/rheumatology/ken280

Macrovascular disease in systemic sclerosis: the tip of an iceberg?

J. J. F. Belch
, S. McSwiggan
, C. Lau

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This mini review evaluates mortality in SSc and provides a literature review concluding that premature death does occur in this population. However, there has been a changing spectrum of cause of death over the past three decades, with interstitial lung disease now being the commonest cause of SSc-related mortality. Cardiovascular (CV) mortality and events also contribute to the premature mortality seen in these patients, and this contention is supported by epidemiological studies, and further underpinned by a plethora of increased biomarkers for CV disease and events. Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population.

Original language	English
Pages (from-to)	V16-V17
Number of pages	2
Journal	Rheumatology
Volume	47
Issue number	Suppl 5
DOIs	https://doi.org/10.1093/rheumatology/ken280
Publication status	Published - 10 Sept 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Systemic Sclerosis
Atherosclerosis
Macrovascular disease
SCLERODERMA
DEATH
MORTALITY
SURVIVAL

ASJC Scopus subject areas

Rheumatology
Pharmacology (medical)

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title = "Macrovascular disease in systemic sclerosis: the tip of an iceberg?",

abstract = "This mini review evaluates mortality in SSc and provides a literature review concluding that premature death does occur in this population. However, there has been a changing spectrum of cause of death over the past three decades, with interstitial lung disease now being the commonest cause of SSc-related mortality. Cardiovascular (CV) mortality and events also contribute to the premature mortality seen in these patients, and this contention is supported by epidemiological studies, and further underpinned by a plethora of increased biomarkers for CV disease and events. Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population.",

keywords = "Systemic Sclerosis, Atherosclerosis, Macrovascular disease, SCLERODERMA, DEATH, MORTALITY, SURVIVAL",

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language = "English",

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}

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T1 - Macrovascular disease in systemic sclerosis

T2 - the tip of an iceberg?

AU - Belch, J. J. F.

AU - McSwiggan, S.

AU - Lau, C.

PY - 2008/9/10

Y1 - 2008/9/10

N2 - This mini review evaluates mortality in SSc and provides a literature review concluding that premature death does occur in this population. However, there has been a changing spectrum of cause of death over the past three decades, with interstitial lung disease now being the commonest cause of SSc-related mortality. Cardiovascular (CV) mortality and events also contribute to the premature mortality seen in these patients, and this contention is supported by epidemiological studies, and further underpinned by a plethora of increased biomarkers for CV disease and events. Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population.

AB - This mini review evaluates mortality in SSc and provides a literature review concluding that premature death does occur in this population. However, there has been a changing spectrum of cause of death over the past three decades, with interstitial lung disease now being the commonest cause of SSc-related mortality. Cardiovascular (CV) mortality and events also contribute to the premature mortality seen in these patients, and this contention is supported by epidemiological studies, and further underpinned by a plethora of increased biomarkers for CV disease and events. Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population.

KW - Systemic Sclerosis

KW - Atherosclerosis

KW - Macrovascular disease

KW - SCLERODERMA

KW - DEATH

KW - MORTALITY

KW - SURVIVAL

UR - https://www.scopus.com/pages/publications/69949163721

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DO - 10.1093/rheumatology/ken280

M3 - Article

C2 - 18784129

SN - 1462-0324

VL - 47

SP - V16-V17

JO - Rheumatology

JF - Rheumatology

IS - Suppl 5

ER -

Macrovascular disease in systemic sclerosis: the tip of an iceberg?

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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