Magnetic resonance imaging assessment of a convective therapy delivery paradigm in a canine prostate model

TY - JOUR

T1 - Magnetic resonance imaging assessment of a convective therapy delivery paradigm in a canine prostate model

AU - Shetty, Anil M.

AU - Stafford, R. Jason

AU - Elliott, Andrew M.

AU - Kassouf, Wassim

AU - Brown, Gordon A.

AU - Stephens, L. Clifton

AU - Tinkey, Peggy T.

AU - Bidaut, Luc

AU - Pisters, Louis L.

AU - Hazle, John D.

PY - 2007/12

Y1 - 2007/12

N2 - Purpose: To quantitatively investigate the feasibility of MRI as a tool for assessing the spatial distribution of a convectively delivered agent using a canine prostate model. Materials and Methods: Canine prostates (ex vivo, n = 3; in vivo, n = 12) were injected under several injection paradigms with a solution of gadolinium-DTPA for MR contrast and methylene blue as a grossly visible surrogate drug marker. Ex vivo and in vivo distributions were assessed at 1.5T and quantitatively compared. Results: Measured distributions using MRI and methylene blue pathology photographs were analyzed using a Bland-Altman method. The fractional percentage volume covered (V) compared the measurements grossly: Pearson's correlation coefficients were R = 0.99 for ex vivo and R = 0.77 for in vivo (P <0.05). The fractional percentage of area covered (A) demonstrated the high degree of spatial correlation between individual slices: R = 0.93 for ex vivo and R = 0.98 for in vivo (P <0.05). There was no statistically observable bias in scale or offset between the measurements. Conclusion: Measured distributions using MRI and pathology were highly correlated and unbiased, indicating the potential of MRI as a tool for quantitative assessment of interstitial delivery of injected therapies in vivo.

AB - Purpose: To quantitatively investigate the feasibility of MRI as a tool for assessing the spatial distribution of a convectively delivered agent using a canine prostate model. Materials and Methods: Canine prostates (ex vivo, n = 3; in vivo, n = 12) were injected under several injection paradigms with a solution of gadolinium-DTPA for MR contrast and methylene blue as a grossly visible surrogate drug marker. Ex vivo and in vivo distributions were assessed at 1.5T and quantitatively compared. Results: Measured distributions using MRI and methylene blue pathology photographs were analyzed using a Bland-Altman method. The fractional percentage volume covered (V) compared the measurements grossly: Pearson's correlation coefficients were R = 0.99 for ex vivo and R = 0.77 for in vivo (P <0.05). The fractional percentage of area covered (A) demonstrated the high degree of spatial correlation between individual slices: R = 0.93 for ex vivo and R = 0.98 for in vivo (P <0.05). There was no statistically observable bias in scale or offset between the measurements. Conclusion: Measured distributions using MRI and pathology were highly correlated and unbiased, indicating the potential of MRI as a tool for quantitative assessment of interstitial delivery of injected therapies in vivo.

UR - https://www.scopus.com/pages/publications/37349102706

U2 - 10.1002/jmri.21206

DO - 10.1002/jmri.21206

M3 - Article

C2 - 17968888

AN - SCOPUS:37349102706

SN - 1053-1807

VL - 26

SP - 1672

EP - 1677

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 6

ER -