MalDA, Accelerating Malaria Drug Discovery

Tuo Yang, Sabine Ottilie, Eva S. Istvan, Karla P. Godinez-Macias, Amanda K. Lukens, Beatriz Baragaña, Brice Campo, Chris Walpole, Jacquin C. Niles, Kelly Chibale, Koen J. Dechering, Manuel Llinás, Marcus C. S. Lee, Nobutaka Kato, Susan Wyllie, Case W. McNamara, Francisco Javier Gamo, Jeremy Burrows, David A. Fidock, Daniel E. GoldbergIan H. Gilbert, Dyann F. Wirth, Elizabeth A. Winzeler,

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)
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Abstract

The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process by identifying new, essential, druggable targets. In addition, it seeks to produce early lead inhibitors that may be advanced into drug candidates suitable for preclinical development and subsequent clinical testing in humans. By sharing resources, including expertise, knowledge, materials, and reagents, the consortium strives to eliminate the structural barriers often encountered in the drug discovery process. Here we discuss the mission of the consortium and its scientific achievements, including the identification of new chemically and biologically validated targets, as well as future scientific directions.

Original languageEnglish
Pages (from-to)493-507
Number of pages15
JournalTrends in Parasitology
Volume37
Issue number6
Early online date26 Feb 2021
DOIs
Publication statusPublished - Jun 2021

Keywords

  • MalDA
  • Plasmodium falciparum
  • drug resistance
  • malaria
  • target-based drug discovery

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