Male contraceptive development: A medicinal chemistry perspective

Neil R. Norcross; Irene Georgiou; Zoe C. Johnston; Franz S. Gruber; Jason R. Swedlow; Kevin D. Read; Christopher L. R. Barratt; Ian H. Gilbert

doi:10.1016/j.ejmech.2022.114709

Male contraceptive development: A medicinal chemistry perspective

Neil R. Norcross, Irene Georgiou, Zoe C. Johnston, Franz S. Gruber, Jason R. Swedlow, Kevin D. Read, Christopher L. R. Barratt, Ian H. Gilbert (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

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Abstract

There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

Original language	English
Article number	114709
Pages (from-to)	1-8
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	243
Early online date	25 Aug 2022
DOIs	https://doi.org/10.1016/j.ejmech.2022.114709
Publication status	Published - 5 Dec 2022

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© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 1.02 MBLicence: CC BY-NC-ND

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abstract = "There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.",

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AU - Norcross, Neil R.

AU - Georgiou, Irene

AU - Johnston, Zoe C.

AU - Gruber, Franz S.

AU - Swedlow, Jason R.

AU - Read, Kevin D.

AU - Barratt, Christopher L. R.

AU - Gilbert, Ian H.

PY - 2022/12/5

Y1 - 2022/12/5

N2 - There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

AB - There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

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DO - 10.1016/j.ejmech.2022.114709

M3 - Review article

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VL - 243

SP - 1

EP - 8

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 114709

ER -

Male contraceptive development: A medicinal chemistry perspective

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Male Contraceptive Drug Development Using a Novel Human Sperm Phenotypic Screening Platform (Grand Challenges Phase II)

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Male contraceptive development: A medicinal chemistry perspective

Abstract

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Male Contraceptive Drug Development Using a Novel Human Sperm Phenotypic Screening Platform (Grand Challenges Phase II)

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