Male contraceptive development: A medicinal chemistry perspective

TY - JOUR

T1 - Male contraceptive development

T2 - A medicinal chemistry perspective

AU - Norcross, Neil R.

AU - Georgiou, Irene

AU - Johnston, Zoe C.

AU - Gruber, Franz S.

AU - Swedlow, Jason R.

AU - Read, Kevin D.

AU - Barratt, Christopher L. R.

AU - Gilbert, Ian H.

N1 - Copyright: © 2022 Published by Elsevier Masson SAS.

PY - 2022/12/5

Y1 - 2022/12/5

N2 - There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

AB - There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

UR - https://www.scopus.com/pages/publications/85137302763

U2 - 10.1016/j.ejmech.2022.114709

DO - 10.1016/j.ejmech.2022.114709

M3 - Review article

C2 - 36087385

SN - 0223-5234

VL - 243

SP - 1

EP - 8

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

M1 - 114709

ER -