Male genital lichen sclerosus and filaggrin

T. N. Shim; S. J. Brown; N. D. Francis; M. Dinneen; D. Hawkins; A. Muneer; S. Minhas; W. H. Irwin McLean; C. B. Bunker

doi:10.1111/ced.14023

Male genital lichen sclerosus and filaggrin

T. N. Shim, S. J. Brown, N. D. Francis, M. Dinneen, D. Hawkins, A. Muneer, S. Minhas, W. H. Irwin McLean, C. B. Bunker (Lead / Corresponding author)

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Abstract

Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.

Original language	English
Pages (from-to)	127-128
Number of pages	2
Journal	Clinical and Experimental Dermatology
Volume	45
Issue number	1
Early online date	17 Jun 2019
DOIs	https://doi.org/10.1111/ced.14023
Publication status	Published - 13 Dec 2019

ASJC Scopus subject areas

Dermatology

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10.1111/ced.14023

Author Accepted ManuscriptAccepted author manuscript, 236 KB

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title = "Male genital lichen sclerosus and filaggrin",

abstract = "Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.",

author = "Shim, {T. N.} and Brown, {S. J.} and Francis, {N. D.} and M. Dinneen and D. Hawkins and A. Muneer and S. Minhas and McLean, {W. H. Irwin} and Bunker, {C. B.}",

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T1 - Male genital lichen sclerosus and filaggrin

AU - Shim, T. N.

AU - Brown, S. J.

AU - Francis, N. D.

AU - Dinneen, M.

AU - Hawkins, D.

AU - Muneer, A.

AU - Minhas, S.

AU - McLean, W. H. Irwin

AU - Bunker, C. B.

PY - 2019/12/13

Y1 - 2019/12/13

N2 - Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.

AB - Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.

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U2 - 10.1111/ced.14023

DO - 10.1111/ced.14023

M3 - Letter

C2 - 31206209

SN - 0307-6938

VL - 45

SP - 127

EP - 128

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

IS - 1

ER -

Male genital lichen sclerosus and filaggrin

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Molecular Mechanisms in Atopic Skin (Senior Research Fellowship in Clinical Science)

Cite this

Male genital lichen sclerosus and filaggrin

Abstract

ASJC Scopus subject areas

Access to Document

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Molecular Mechanisms in Atopic Skin (Senior Research Fellowship in Clinical Science)

Cite this