Male genital lichen sclerosus and filaggrin

Tang N. Shim, Sara J. Brown, N. D. Francis, M. Dinneen, D. Hawkins, A. Muneer, S. Minhas, W. H. Irwin McLean, Christopher B. Bunker (Lead / Corresponding author)

Research output: Contribution to journalLetter

Abstract

Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.
Original languageEnglish
Number of pages2
JournalClinical and Experimental Dermatology
Early online date17 Jun 2019
DOIs
Publication statusE-pub ahead of print - 17 Jun 2019

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Lichen Sclerosus et Atrophicus
Genitalia
Autoimmunity
Skin Diseases
Epidermis
Epithelium
Urine
Infection
Proteins
filaggrin

Cite this

Shim, T. N., Brown, S. J., Francis, N. D., Dinneen, M., Hawkins, D., Muneer, A., ... Bunker, C. B. (2019). Male genital lichen sclerosus and filaggrin. Clinical and Experimental Dermatology. https://doi.org/10.1111/ced.14023
Shim, Tang N. ; Brown, Sara J. ; Francis, N. D. ; Dinneen, M. ; Hawkins, D. ; Muneer, A. ; Minhas, S. ; McLean, W. H. Irwin ; Bunker, Christopher B. / Male genital lichen sclerosus and filaggrin. In: Clinical and Experimental Dermatology. 2019.
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Shim, TN, Brown, SJ, Francis, ND, Dinneen, M, Hawkins, D, Muneer, A, Minhas, S, McLean, WHI & Bunker, CB 2019, 'Male genital lichen sclerosus and filaggrin', Clinical and Experimental Dermatology. https://doi.org/10.1111/ced.14023

Male genital lichen sclerosus and filaggrin. / Shim, Tang N.; Brown, Sara J.; Francis, N. D.; Dinneen, M.; Hawkins, D.; Muneer, A.; Minhas, S.; McLean, W. H. Irwin; Bunker, Christopher B. (Lead / Corresponding author).

In: Clinical and Experimental Dermatology, 17.06.2019.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Male genital lichen sclerosus and filaggrin

AU - Shim, Tang N.

AU - Brown, Sara J.

AU - Francis, N. D.

AU - Dinneen, M.

AU - Hawkins, D.

AU - Muneer, A.

AU - Minhas, S.

AU - McLean, W. H. Irwin

AU - Bunker, Christopher B.

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AB - Lichen sclerosus (LSc) is an acquired cutaneous disease of contentious aetiology. The majority of male cases involve the genitalia. Amongst prior postulated pathogenic factors in genital (G)LSc are infection, autoimmunity and genetic and environmental influences.1 There is an arguement that male (M)GLSc might be due to chronic occluded exposure of susceptible epithelium to urine. GLSc has also been associated with atopy.2 Filaggrin is a key epithelial protein expressed during terminal differentiation of the epidermis, forming a component of the epithelial barrier.

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