Male Infertility and antioxidants: one small step for man, no giant leap for andrology?

Sarah J. Martins da Silva (Lead / Corresponding author)

Research output: Contribution to journalComment/debate

36 Downloads (Pure)

Abstract

Oxidative stress is detrimental to spermatozoa and is acknowledged to be a common pathology in infertile men. Antioxidant supplements, therefore, represent a logical therapeutic approach, although the recent Cochrane review recommends cautious interpretation of publications and findings to date. This commentary considers whether male fertility supplements have a place in current reproductive medicine practice. Importantly, although sperm selection for intracytoplasmic sperm injection is a common research theme, survey data show that men would prefer medication to achieve natural conception, rather than treatment to improve assisted reproductive technology (ART) success. A total of 27.1% (n = 112), 26.6% (n = 110) and 24.5% (n = 101) respondents indicated they (or their male partner) would undertake medical treatment to attempt natural conception for up to 6 months, 12 months and 2 years, respectively. A total of 63% indicated that they would be prepared to participate in a clinical trial and 57% would defer ART by 6 months to do so. This information represents the beginnings of a dialogue with patients and stakeholders and should be used to shape research efforts.

Original languageEnglish
Pages (from-to)879-883
Number of pages5
JournalReproductive BioMedicine Online
Volume39
Issue number6
Early online date3 Sep 2019
DOIs
Publication statusE-pub ahead of print - 3 Sep 2019

Fingerprint

Andrology
Male Infertility
Assisted Reproductive Techniques
Antioxidants
Spermatozoa
Reproductive Medicine
Intracytoplasmic Sperm Injections
Research
Fertility
Publications
Oxidative Stress
Therapeutics
Clinical Trials
Pathology
Surveys and Questionnaires

Cite this

@article{c75235273ab348cfbbb73c5fec22ebb1,
title = "Male Infertility and antioxidants: one small step for man, no giant leap for andrology?",
abstract = "Oxidative stress is detrimental to spermatozoa and is acknowledged to be a common pathology in infertile men. Antioxidant supplements, therefore, represent a logical therapeutic approach, although the recent Cochrane review recommends cautious interpretation of publications and findings to date. This commentary considers whether male fertility supplements have a place in current reproductive medicine practice. Importantly, although sperm selection for intracytoplasmic sperm injection is a common research theme, survey data show that men would prefer medication to achieve natural conception, rather than treatment to improve assisted reproductive technology (ART) success. A total of 27.1{\%} (n = 112), 26.6{\%} (n = 110) and 24.5{\%} (n = 101) respondents indicated they (or their male partner) would undertake medical treatment to attempt natural conception for up to 6 months, 12 months and 2 years, respectively. A total of 63{\%} indicated that they would be prepared to participate in a clinical trial and 57{\%} would defer ART by 6 months to do so. This information represents the beginnings of a dialogue with patients and stakeholders and should be used to shape research efforts.",
author = "{Martins da Silva}, {Sarah J.}",
note = "Crown Copyright {\circledC} 2019. Licensed under the Open Government Licence v3.0.",
year = "2019",
month = "9",
day = "3",
doi = "10.1016/j.rbmo.2019.08.008",
language = "English",
volume = "39",
pages = "879--883",
journal = "Reproductive BioMedicine Online",
issn = "1472-6483",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Male Infertility and antioxidants

T2 - one small step for man, no giant leap for andrology?

AU - Martins da Silva, Sarah J.

N1 - Crown Copyright © 2019. Licensed under the Open Government Licence v3.0.

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Oxidative stress is detrimental to spermatozoa and is acknowledged to be a common pathology in infertile men. Antioxidant supplements, therefore, represent a logical therapeutic approach, although the recent Cochrane review recommends cautious interpretation of publications and findings to date. This commentary considers whether male fertility supplements have a place in current reproductive medicine practice. Importantly, although sperm selection for intracytoplasmic sperm injection is a common research theme, survey data show that men would prefer medication to achieve natural conception, rather than treatment to improve assisted reproductive technology (ART) success. A total of 27.1% (n = 112), 26.6% (n = 110) and 24.5% (n = 101) respondents indicated they (or their male partner) would undertake medical treatment to attempt natural conception for up to 6 months, 12 months and 2 years, respectively. A total of 63% indicated that they would be prepared to participate in a clinical trial and 57% would defer ART by 6 months to do so. This information represents the beginnings of a dialogue with patients and stakeholders and should be used to shape research efforts.

AB - Oxidative stress is detrimental to spermatozoa and is acknowledged to be a common pathology in infertile men. Antioxidant supplements, therefore, represent a logical therapeutic approach, although the recent Cochrane review recommends cautious interpretation of publications and findings to date. This commentary considers whether male fertility supplements have a place in current reproductive medicine practice. Importantly, although sperm selection for intracytoplasmic sperm injection is a common research theme, survey data show that men would prefer medication to achieve natural conception, rather than treatment to improve assisted reproductive technology (ART) success. A total of 27.1% (n = 112), 26.6% (n = 110) and 24.5% (n = 101) respondents indicated they (or their male partner) would undertake medical treatment to attempt natural conception for up to 6 months, 12 months and 2 years, respectively. A total of 63% indicated that they would be prepared to participate in a clinical trial and 57% would defer ART by 6 months to do so. This information represents the beginnings of a dialogue with patients and stakeholders and should be used to shape research efforts.

UR - http://www.scopus.com/inward/record.url?scp=85075343299&partnerID=8YFLogxK

U2 - 10.1016/j.rbmo.2019.08.008

DO - 10.1016/j.rbmo.2019.08.008

M3 - Comment/debate

C2 - 31727498

VL - 39

SP - 879

EP - 883

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

SN - 1472-6483

IS - 6

ER -