Malignant epithelial neoplasms of the large intestine

Shaun V. Walsh; Kieran Sheahan; Frank A. Carey

doi:10.1002/9781119423195.ch38

Malignant epithelial neoplasms of the large intestine

Shaun V. Walsh
, Kieran Sheahan
, Frank A. Carey

MED Cancer Research

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Adenocarcinomas of the large bowel are among the most common human malignancies. This chapter discusses the epidemiology and pathogenesis of large-bowel cancer. It reviews aspects of epidemiology, biology, pathology and modern therapy that will provide a richer understanding of the context in which a particular specimen is interpreted. The chapter also discusses the concepts arising from the inherited pathways, allowing the introduction of specific molecular genetic data relevant to sporadic pathways. The aetiology of colorectal cancer encompasses both environmental and endogenous influences. Colorectal carcinoma may begin with the inheritance of a mutated tumour suppressor gene, as with familial adenomatous polyposis and Lynch syndrome. Small-cell and large-cell undifferentiated carcinoma may be placed at the most malignant end of the neuroendocrine spectrum. Microscopic grading of colorectal cancer has long been part of routine pathology practice. Glandular architecture is obvious in most colorectal cancer and is characteristic of well-differentiated and moderately differentiated neoplasms.

Original language	English
Title of host publication	Morson and Dawson’s Gastrointestinal Pathology
Editors	Adrian C Bateman, Joel K Greenson, Gregory Y Lauwers, Maurice B Loughrey, Marco R Novelli, Kieran Sheahan, Neil A Shepherd
Publisher	Wiley
Pages	925-967
Number of pages	43
Edition	6
ISBN (Electronic)	9781119423195
ISBN (Print)	9781119423188
DOIs	https://doi.org/10.1002/9781119423195.ch38
Publication status	Published - 16 Sept 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adenocarcinoma
colorectal cancer
epidemiology
large intestine
malignant epithelial neoplasms
pathogenesis

ASJC Scopus subject areas

General Medicine

Access to Document

10.1002/9781119423195.ch38

Cite this

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abstract = "Adenocarcinomas of the large bowel are among the most common human malignancies. This chapter discusses the epidemiology and pathogenesis of large-bowel cancer. It reviews aspects of epidemiology, biology, pathology and modern therapy that will provide a richer understanding of the context in which a particular specimen is interpreted. The chapter also discusses the concepts arising from the inherited pathways, allowing the introduction of specific molecular genetic data relevant to sporadic pathways. The aetiology of colorectal cancer encompasses both environmental and endogenous influences. Colorectal carcinoma may begin with the inheritance of a mutated tumour suppressor gene, as with familial adenomatous polyposis and Lynch syndrome. Small-cell and large-cell undifferentiated carcinoma may be placed at the most malignant end of the neuroendocrine spectrum. Microscopic grading of colorectal cancer has long been part of routine pathology practice. Glandular architecture is obvious in most colorectal cancer and is characteristic of well-differentiated and moderately differentiated neoplasms.",

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Malignant epithelial neoplasms of the large intestine. / Walsh, Shaun V.; Sheahan, Kieran; Carey, Frank A.
Morson and Dawson’s Gastrointestinal Pathology. ed. / Adrian C Bateman; Joel K Greenson; Gregory Y Lauwers; Maurice B Loughrey; Marco R Novelli; Kieran Sheahan; Neil A Shepherd. 6. ed. Wiley, 2024. p. 925-967.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Malignant epithelial neoplasms of the large intestine

AU - Walsh, Shaun V.

AU - Sheahan, Kieran

AU - Carey, Frank A.

PY - 2024/9/16

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AB - Adenocarcinomas of the large bowel are among the most common human malignancies. This chapter discusses the epidemiology and pathogenesis of large-bowel cancer. It reviews aspects of epidemiology, biology, pathology and modern therapy that will provide a richer understanding of the context in which a particular specimen is interpreted. The chapter also discusses the concepts arising from the inherited pathways, allowing the introduction of specific molecular genetic data relevant to sporadic pathways. The aetiology of colorectal cancer encompasses both environmental and endogenous influences. Colorectal carcinoma may begin with the inheritance of a mutated tumour suppressor gene, as with familial adenomatous polyposis and Lynch syndrome. Small-cell and large-cell undifferentiated carcinoma may be placed at the most malignant end of the neuroendocrine spectrum. Microscopic grading of colorectal cancer has long been part of routine pathology practice. Glandular architecture is obvious in most colorectal cancer and is characteristic of well-differentiated and moderately differentiated neoplasms.

KW - adenocarcinoma

KW - colorectal cancer

KW - epidemiology

KW - large intestine

KW - malignant epithelial neoplasms

KW - pathogenesis

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A2 - Greenson, Joel K

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A2 - Novelli, Marco R

A2 - Sheahan, Kieran

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ER -

Malignant epithelial neoplasms of the large intestine

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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