"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies"

Julio A. Ramirez; Daniel M. Musher; Scott E. Evans; Charles Dela Cruz; Kristina A. Crothers; Chadi A. Hage; Stefano Aliberti; Antonio Anzueto; Francisco Arancibia; Forest Arnold; Elie Azoulay; Francesco Blasi; Jose Bordon; Steven Burdette; Bin Cao; Rodrigo Cavallazzi; James Chalmers; Patrick Charles; Jean Chastre; Yann-Erick Claessens; Nathan Dean; Xavier Duval; Muriel Fartoukh; Charles Feldman; Thomas File; Filipe Froes; Stephen Furmanek; Martin Gnoni; Gustavo Lopardo; Carlos Luna; Takaya Maruyama; Rosario Menendez; Mark Metersky; Donna Mildvan; Eric Mortensen; Michael S. Niederman; Mathias Pletz; Jordi Rello; Marcos I. Restrepo; Yuichiro Shindo; Antoni Torres; Grant Waterer; Brandon Webb; Tobias Welte; Martin Witzenrath; Richard Wunderink

doi:10.1016/j.chest.2020.05.598

"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies"

Julio A. Ramirez (Lead / Corresponding author), Daniel M. Musher, Scott E. Evans, Charles Dela Cruz, Kristina A. Crothers, Chadi A. Hage, Stefano Aliberti, Antonio Anzueto, Francisco Arancibia, Forest Arnold, Elie Azoulay, Francesco Blasi, Jose Bordon, Steven Burdette, Bin Cao, Rodrigo Cavallazzi, James Chalmers, Patrick Charles, Jean Chastre, Yann-Erick ClaessensNathan Dean, Xavier Duval, Muriel Fartoukh, Charles Feldman, Thomas File, Filipe Froes, Stephen Furmanek, Martin Gnoni, Gustavo Lopardo, Carlos Luna, Takaya Maruyama, Rosario Menendez, Mark Metersky, Donna Mildvan, Eric Mortensen, Michael S. Niederman, Mathias Pletz, Jordi Rello, Marcos I. Restrepo, Yuichiro Shindo, Antoni Torres, Grant Waterer, Brandon Webb, Tobias Welte, Martin Witzenrath, Richard Wunderink

Molecular and Clinical Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients.

Research Question: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP.

Study Design and Methods: This consensus document was created by a multidisciplinary panel of 45 physicians with experience in the management of CAP in immunocompromised patients. The Delphi survey methodology was used to reach consensus.

Results: The panel focused on 21 questions addressing initial management strategies. The panel achieved consensus in defining the population, site of care, likely pathogens, microbiological work-up, general principles of empiric therapy, and empiric therapy for specific pathogens.

Interpretation: This document offer general suggestions for the initial management of the immunocompromised patient who arrives at the hospital with pneumonia.

Original language	English
Journal	Chest
Early online date	16 Jun 2020
DOIs	https://doi.org/10.1016/j.chest.2020.05.598
Publication status	E-pub ahead of print - 16 Jun 2020

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10.1016/j.chest.2020.05.598

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Embargo ends: 16/06/21

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Ramirez, J. A., Musher, D. M., Evans, S. E., Dela Cruz, C., Crothers, K. A., Hage, C. A., Aliberti, S., Anzueto, A., Arancibia, F., Arnold, F., Azoulay, E., Blasi, F., Bordon, J., Burdette, S., Cao, B., Cavallazzi, R., Chalmers, J., Charles, P., Chastre, J., ... Wunderink, R. (2020). "Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies". Chest. https://doi.org/10.1016/j.chest.2020.05.598

Ramirez, Julio A. ; Musher, Daniel M. ; Evans, Scott E. ; Dela Cruz, Charles ; Crothers, Kristina A. ; Hage, Chadi A. ; Aliberti, Stefano ; Anzueto, Antonio ; Arancibia, Francisco ; Arnold, Forest ; Azoulay, Elie ; Blasi, Francesco ; Bordon, Jose ; Burdette, Steven ; Cao, Bin ; Cavallazzi, Rodrigo ; Chalmers, James ; Charles, Patrick ; Chastre, Jean ; Claessens, Yann-Erick ; Dean, Nathan ; Duval, Xavier ; Fartoukh, Muriel ; Feldman, Charles ; File, Thomas ; Froes, Filipe ; Furmanek, Stephen ; Gnoni, Martin ; Lopardo, Gustavo ; Luna, Carlos ; Maruyama, Takaya ; Menendez, Rosario ; Metersky, Mark ; Mildvan, Donna ; Mortensen, Eric ; Niederman, Michael S. ; Pletz, Mathias ; Rello, Jordi ; Restrepo, Marcos I. ; Shindo, Yuichiro ; Torres, Antoni ; Waterer, Grant ; Webb, Brandon ; Welte, Tobias ; Witzenrath, Martin ; Wunderink, Richard. / "Management of Community-Acquired Pneumonia in Immunocompromised Adults : A Consensus Statement Regarding Initial Strategies". In: Chest. 2020.

@article{1b44d09f89f9455a978889275b29004f,

title = "{"}Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies{"}",

abstract = "Background: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients.Research Question: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP.Study Design and Methods: This consensus document was created by a multidisciplinary panel of 45 physicians with experience in the management of CAP in immunocompromised patients. The Delphi survey methodology was used to reach consensus.Results: The panel focused on 21 questions addressing initial management strategies. The panel achieved consensus in defining the population, site of care, likely pathogens, microbiological work-up, general principles of empiric therapy, and empiric therapy for specific pathogens.Interpretation: This document offer general suggestions for the initial management of the immunocompromised patient who arrives at the hospital with pneumonia.",

author = "Ramirez, {Julio A.} and Musher, {Daniel M.} and Evans, {Scott E.} and {Dela Cruz}, Charles and Crothers, {Kristina A.} and Hage, {Chadi A.} and Stefano Aliberti and Antonio Anzueto and Francisco Arancibia and Forest Arnold and Elie Azoulay and Francesco Blasi and Jose Bordon and Steven Burdette and Bin Cao and Rodrigo Cavallazzi and James Chalmers and Patrick Charles and Jean Chastre and Yann-Erick Claessens and Nathan Dean and Xavier Duval and Muriel Fartoukh and Charles Feldman and Thomas File and Filipe Froes and Stephen Furmanek and Martin Gnoni and Gustavo Lopardo and Carlos Luna and Takaya Maruyama and Rosario Menendez and Mark Metersky and Donna Mildvan and Eric Mortensen and Niederman, {Michael S.} and Mathias Pletz and Jordi Rello and Restrepo, {Marcos I.} and Yuichiro Shindo and Antoni Torres and Grant Waterer and Brandon Webb and Tobias Welte and Martin Witzenrath and Richard Wunderink",

note = "Sponsored by the International Respiratory Infection Society Copyright {\textcopyright} 2020. Published by Elsevier Inc.",

year = "2020",

month = jun,

day = "16",

doi = "10.1016/j.chest.2020.05.598",

language = "English",

journal = "Chest",

issn = "0012-3692",

publisher = "Elsevier",

}

Ramirez, JA, Musher, DM, Evans, SE, Dela Cruz, C, Crothers, KA, Hage, CA, Aliberti, S, Anzueto, A, Arancibia, F, Arnold, F, Azoulay, E, Blasi, F, Bordon, J, Burdette, S, Cao, B, Cavallazzi, R, Chalmers, J, Charles, P, Chastre, J, Claessens, Y-E, Dean, N, Duval, X, Fartoukh, M, Feldman, C, File, T, Froes, F, Furmanek, S, Gnoni, M, Lopardo, G, Luna, C, Maruyama, T, Menendez, R, Metersky, M, Mildvan, D, Mortensen, E, Niederman, MS, Pletz, M, Rello, J, Restrepo, MI, Shindo, Y, Torres, A, Waterer, G, Webb, B, Welte, T, Witzenrath, M & Wunderink, R 2020, '"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies"', Chest. https://doi.org/10.1016/j.chest.2020.05.598

"Management of Community-Acquired Pneumonia in Immunocompromised Adults : A Consensus Statement Regarding Initial Strategies". / Ramirez, Julio A. (Lead / Corresponding author); Musher, Daniel M.; Evans, Scott E.; Dela Cruz, Charles; Crothers, Kristina A.; Hage, Chadi A.; Aliberti, Stefano; Anzueto, Antonio; Arancibia, Francisco; Arnold, Forest; Azoulay, Elie; Blasi, Francesco; Bordon, Jose; Burdette, Steven; Cao, Bin; Cavallazzi, Rodrigo; Chalmers, James; Charles, Patrick; Chastre, Jean; Claessens, Yann-Erick; Dean, Nathan; Duval, Xavier; Fartoukh, Muriel; Feldman, Charles; File, Thomas; Froes, Filipe; Furmanek, Stephen; Gnoni, Martin; Lopardo, Gustavo; Luna, Carlos; Maruyama, Takaya; Menendez, Rosario; Metersky, Mark; Mildvan, Donna; Mortensen, Eric; Niederman, Michael S.; Pletz, Mathias; Rello, Jordi; Restrepo, Marcos I.; Shindo, Yuichiro; Torres, Antoni; Waterer, Grant; Webb, Brandon; Welte, Tobias; Witzenrath, Martin; Wunderink, Richard.

In: Chest, 16.06.2020.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - "Management of Community-Acquired Pneumonia in Immunocompromised Adults

T2 - A Consensus Statement Regarding Initial Strategies"

AU - Ramirez, Julio A.

AU - Musher, Daniel M.

AU - Evans, Scott E.

AU - Dela Cruz, Charles

AU - Crothers, Kristina A.

AU - Hage, Chadi A.

AU - Aliberti, Stefano

AU - Anzueto, Antonio

AU - Arancibia, Francisco

AU - Arnold, Forest

AU - Azoulay, Elie

AU - Blasi, Francesco

AU - Bordon, Jose

AU - Burdette, Steven

AU - Cao, Bin

AU - Cavallazzi, Rodrigo

AU - Chalmers, James

AU - Charles, Patrick

AU - Chastre, Jean

AU - Claessens, Yann-Erick

AU - Dean, Nathan

AU - Duval, Xavier

AU - Fartoukh, Muriel

AU - Feldman, Charles

AU - File, Thomas

AU - Froes, Filipe

AU - Furmanek, Stephen

AU - Gnoni, Martin

AU - Lopardo, Gustavo

AU - Luna, Carlos

AU - Maruyama, Takaya

AU - Menendez, Rosario

AU - Metersky, Mark

AU - Mildvan, Donna

AU - Mortensen, Eric

AU - Niederman, Michael S.

AU - Pletz, Mathias

AU - Rello, Jordi

AU - Restrepo, Marcos I.

AU - Shindo, Yuichiro

AU - Torres, Antoni

AU - Waterer, Grant

AU - Webb, Brandon

AU - Welte, Tobias

AU - Witzenrath, Martin

AU - Wunderink, Richard

PY - 2020/6/16

Y1 - 2020/6/16

N2 - Background: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients.Research Question: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP.Study Design and Methods: This consensus document was created by a multidisciplinary panel of 45 physicians with experience in the management of CAP in immunocompromised patients. The Delphi survey methodology was used to reach consensus.Results: The panel focused on 21 questions addressing initial management strategies. The panel achieved consensus in defining the population, site of care, likely pathogens, microbiological work-up, general principles of empiric therapy, and empiric therapy for specific pathogens.Interpretation: This document offer general suggestions for the initial management of the immunocompromised patient who arrives at the hospital with pneumonia.

AB - Background: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients.Research Question: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP.Study Design and Methods: This consensus document was created by a multidisciplinary panel of 45 physicians with experience in the management of CAP in immunocompromised patients. The Delphi survey methodology was used to reach consensus.Results: The panel focused on 21 questions addressing initial management strategies. The panel achieved consensus in defining the population, site of care, likely pathogens, microbiological work-up, general principles of empiric therapy, and empiric therapy for specific pathogens.Interpretation: This document offer general suggestions for the initial management of the immunocompromised patient who arrives at the hospital with pneumonia.

UR - http://www.scopus.com/inward/record.url?scp=85086785751&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2020.05.598

DO - 10.1016/j.chest.2020.05.598

M3 - Review article

C2 - 32561442

JO - Chest

JF - Chest

SN - 0012-3692

ER -