Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study

, Julie Delyon, Clementine Rabate, Sylvie Euvrard, Catherine A. Harwood, Charlotte Proby, A. Tülin Güleç, Deniz Seçkin, Veronique Del Marmol, Jan Nico Bouwes-Bavinck, Carla Ferrándiz-Pulido, Maria Andrea Ocampo, Stephane Barete, Christophe Legendre, Camille Francès, Raphael Porcher, Celeste Lebbe

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
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Background: Systemic therapeutic management of post-transplant Kaposi sarcoma (KS) is mainly based on 3 axes: reduction of immunosuppression, conversion to mammalian target of rapamycin (mTOR) inhibitors, chemotherapy, or a combination of these.

Objective: To obtain an overview of clinical strategies about the current treatment of KS. Methods: We conducted a multicenter retrospective cohort study including 145 solid organ transplant recipients diagnosed with KS between 1985 and 2011 to collect data regarding first-line treatment and response at 6 months.

Results: Overall, 95%, 28%, and 16% of patients had reduction of immunosuppression, conversion to mTOR inhibitor, and chemotherapy, respectively. Patients treated with chemotherapy or mTOR inhibitor conversion were more likely to have visceral KS. At 6 months, 83% of patients had response, including 40% complete responses.

Limitations: The retrospective design of the study.

Conclusion: Currently available therapeutic options seem to be effective to control KS in most patients. Tapering down the immunosuppressive regimen remains the cornerstone of KS management.

Original languageEnglish
Pages (from-to)448-455
Number of pages8
JournalJournal of the American Academy of Dermatology
Issue number2
Early online date19 Mar 2019
Publication statusPublished - Aug 2019


  • chemotherapy
  • immunosuppression
  • Kaposi sarcoma
  • mTOR inhibitor
  • organ transplantation
  • post-transplant malignancies

ASJC Scopus subject areas

  • Dermatology


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