Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study

, Julie Delyon, Clementine Rabate, Sylvie Euvrard, Catherine A. Harwood, Charlotte Proby, A. Tülin Güleç, Deniz Seçkin, Veronique Del Marmol, Jan Nico Bouwes-Bavinck, Carla Ferrándiz-Pulido, Maria Andrea Ocampo, Stephane Barete, Christophe Legendre, Camille Francès, Raphael Porcher, Celeste Lebbe

Research output: Contribution to journalArticle

4 Citations (Scopus)
18 Downloads (Pure)

Abstract

Background: Systemic therapeutic management of post-transplant Kaposi sarcoma (KS) is mainly based on 3 axes: reduction of immunosuppression, conversion to mammalian target of rapamycin (mTOR) inhibitors, chemotherapy, or a combination of these.

Objective: To obtain an overview of clinical strategies about the current treatment of KS. Methods: We conducted a multicenter retrospective cohort study including 145 solid organ transplant recipients diagnosed with KS between 1985 and 2011 to collect data regarding first-line treatment and response at 6 months.

Results: Overall, 95%, 28%, and 16% of patients had reduction of immunosuppression, conversion to mTOR inhibitor, and chemotherapy, respectively. Patients treated with chemotherapy or mTOR inhibitor conversion were more likely to have visceral KS. At 6 months, 83% of patients had response, including 40% complete responses.

Limitations: The retrospective design of the study.

Conclusion: Currently available therapeutic options seem to be effective to control KS in most patients. Tapering down the immunosuppressive regimen remains the cornerstone of KS management.

Original languageEnglish
Pages (from-to)448-455
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume81
Issue number2
Early online date19 Mar 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • chemotherapy
  • immunosuppression
  • Kaposi sarcoma
  • mTOR inhibitor
  • organ transplantation
  • post-transplant malignancies

Fingerprint Dive into the research topics of 'Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study'. Together they form a unique fingerprint.

  • Cite this

    , Delyon, J., Rabate, C., Euvrard, S., Harwood, C. A., Proby, C., Güleç, A. T., Seçkin, D., Del Marmol, V., Bouwes-Bavinck, J. N., Ferrándiz-Pulido, C., Ocampo, M. A., Barete, S., Legendre, C., Francès, C., & Porcher, R., & Lebbe, C. (2019). Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study. Journal of the American Academy of Dermatology, 81(2), 448-455. https://doi.org/10.1016/j.jaad.2019.03.028