Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee

Onyebuchi Okosieme, Jackie Gilbert, Prakash Abraham, Kristien Boelaert, Colin Dayan, Mark Gurnell, Graham Leese, Christopher McCabe, Petros Perros, Vicki Smith, Graham Williams, Mark Vanderpump (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    62 Citations (Scopus)

    Abstract

    The management of primary hypothyroidism with levothyroxine (L-T4) is simple, effective and safe, and most patients report improved well-being on initiation of treatment. However, a proportion of individuals continue to suffer with symptoms despite achieving adequate biochemical correction. The management of such individuals has been the subject of controversy and of considerable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism. These guidelines have been based on extensive reviews of the medical literature and include sections on the role of combination therapy with L-T4 and liothyronine (L-T3) in individuals who are persistently dissatisfied with L-T4 therapy. This position statement by the British Thyroid Association (BTA) summarises the key points in these guidelines and makes recommendations on the management of primary hypothyroidism based on the current literature, review of the published positions of the ETA and ATA, and in line with best principles of good medical practice. The statement is endorsed by the Association of Clinical Biochemistry, (ACB), British Thyroid Foundation, (BTF), Royal College of Physicians (RCP) and Society for Endocrinology (SFE).

    Original languageEnglish
    Pages (from-to)799-808
    Number of pages10
    JournalClinical Endocrinology
    Volume84
    Issue number6
    Early online date23 Jun 2015
    DOIs
    Publication statusPublished - Jun 2016

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