Mapping tissue shear modulus on Thiel soft-embalmed mouse skin with shear wave optical coherence elastography

Shaozhen Song, Joyce Joy, Ruikang K. Wang, Zhihong Huang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    A quantitative measurement of the mechanical properties of biological tissue is a useful assessment of its physiologic conditions, which may aid medical diagnosis and treatment of, e.g., scleroderma and skin cancer. Traditional elastography techniques such as magnetic resonance elastography and ultrasound elastography have limited scope of application on skin due to insufficient spatial resolution. Recently, dynamic/transient elastography are attracting more applications with the advantage of non-destructive measurements, and revealing the absolute moduli values of tissue mechanical properties. Shear wave optical coherence elastography (SW-OCE) is a novel transient elastography method, which lays emphasis on the propagation of dynamic mechanical waves. In this study, high speed shear wave imaging technique was applied to a range of soft-embalmed mouse skin, where 3 kHz shear waves were launched with a piezoelectric actuator as an external excitation. The shear wave velocity were estimated from the shear wave images, and used to recover a shear modulus map in the same OCT imaging range. Results revealed significant difference in shear modulus and structure in compliance with gender, and images on fresh mouse skin are also compared. Thiel embalming technique is also proved to present the ability to furthest preserve the mechanical property of biological tissue. The experiment results suggest that SW-OCE is an effective technique for quantitative estimation of skin tissue biomechanical status.

    Original languageEnglish
    Title of host publicationOptical Elastography and Tissue Biomechanics II
    EditorsKirill V. Larin, David D. Sampson
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628414172
    Publication statusPublished - 2015
    EventSPIE Photonics West 2015: Optical Elastography and Tissue Biomechanics II - Moscone Center, San Francisco, United States
    Duration: 7 Feb 20158 Feb 2015

    Publication series

    NameProceedings of SPIE
    NameProgress in Biomedical Optics and Imaging


    ConferenceSPIE Photonics West 2015: Optical Elastography and Tissue Biomechanics II
    Country/TerritoryUnited States
    CitySan Francisco
    Internet address


    • Dynamic elastography
    • Optical coherence elastography
    • Shear wave imaging
    • Thiel embalming

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging


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