Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis

Neil Basu (Lead / Corresponding author), Andrew Mcclean, Lorraine Harper, Esther N. Amft, Neerja Dhaun, Rashid A. Luqmani, Mark A. Little, David R. W. Jayne, Oliver Flossmann, John Mclaren, Vinod Kumar, Lars P. Erwig, David M. Reid, Gary J. Macfarlane, Gareth T. Jones

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Objectives: ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work disability is an important outcome for both patient and society that has yet to be fully evaluated in AAV. We aimed to assess employment status in AAV patients and identify putative predictors of their work disability. Methods: A cross-sectional study was undertaken. AAV cases were recruited according to consecutive clinic attendance. Subjects completed a questionnaire that determined employment status and other psychosocial measures. Clinical factors were concurrently recorded by the attending physician. From the data of those subjects of working age, a multivariable model was developed using forward stepwise logistic regression to identify the independent associations of work disability, defined by those subjects reporting unemployment secondary to ill-health. Results are expressed as odds ratios (ORs) and 95% CIs. Results: Of the 410 participants (84.4% response rate), 149 (36.7%) were employed, 197 (48.6%) retired and 54 (13.3%) unemployed secondary to ill health. Of those of working age, 26.0% were considered work disabled. Fatigue (OR 7.1, 95% CI 1.5, 33.1), depression (OR 4.4, 95% CI 1.8, 10.8), severe disease damage [Vasculitis Damage Index (VDI) > 4 (OR 3.9, 95% CI 1.01, 14.7)] and being overweight (OR 3.4, 95% CI 1.3, 8.9) were independently associated with their unemployment. Conclusion: A quarter of working-age AAV subjects reported unemployment as a result of ill health and are characterized by high levels of fatigue, depression, disease damage and being overweight. These potentially modifiable factors may inform future multidisciplinary interventions aimed at alleviating work disability. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
    Original languageEnglish
    Pages (from-to)953-956
    Number of pages4
    JournalRheumatology
    Volume53
    Issue number5
    Early online date31 Jan 2014
    DOIs
    Publication statusPublished - 2014

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    Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
    Odds Ratio
    Unemployment
    Fatigue
    Health
    Vasculitis
    Survival Rate
    Cross-Sectional Studies
    Logistic Models
    Depression
    Physicians

    Cite this

    Basu, N., Mcclean, A., Harper, L., Amft, E. N., Dhaun, N., Luqmani, R. A., ... Jones, G. T. (2014). Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis. Rheumatology, 53(5), 953-956. https://doi.org/10.1093/rheumatology/ket483
    Basu, Neil ; Mcclean, Andrew ; Harper, Lorraine ; Amft, Esther N. ; Dhaun, Neerja ; Luqmani, Rashid A. ; Little, Mark A. ; Jayne, David R. W. ; Flossmann, Oliver ; Mclaren, John ; Kumar, Vinod ; Erwig, Lars P. ; Reid, David M. ; Macfarlane, Gary J. ; Jones, Gareth T. / Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis. In: Rheumatology. 2014 ; Vol. 53, No. 5. pp. 953-956.
    @article{46d13555c3d04f6fa9ca7fe83e200205,
    title = "Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis",
    abstract = "Objectives: ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work disability is an important outcome for both patient and society that has yet to be fully evaluated in AAV. We aimed to assess employment status in AAV patients and identify putative predictors of their work disability. Methods: A cross-sectional study was undertaken. AAV cases were recruited according to consecutive clinic attendance. Subjects completed a questionnaire that determined employment status and other psychosocial measures. Clinical factors were concurrently recorded by the attending physician. From the data of those subjects of working age, a multivariable model was developed using forward stepwise logistic regression to identify the independent associations of work disability, defined by those subjects reporting unemployment secondary to ill-health. Results are expressed as odds ratios (ORs) and 95{\%} CIs. Results: Of the 410 participants (84.4{\%} response rate), 149 (36.7{\%}) were employed, 197 (48.6{\%}) retired and 54 (13.3{\%}) unemployed secondary to ill health. Of those of working age, 26.0{\%} were considered work disabled. Fatigue (OR 7.1, 95{\%} CI 1.5, 33.1), depression (OR 4.4, 95{\%} CI 1.8, 10.8), severe disease damage [Vasculitis Damage Index (VDI) > 4 (OR 3.9, 95{\%} CI 1.01, 14.7)] and being overweight (OR 3.4, 95{\%} CI 1.3, 8.9) were independently associated with their unemployment. Conclusion: A quarter of working-age AAV subjects reported unemployment as a result of ill health and are characterized by high levels of fatigue, depression, disease damage and being overweight. These potentially modifiable factors may inform future multidisciplinary interventions aimed at alleviating work disability. {\circledC} The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.",
    author = "Neil Basu and Andrew Mcclean and Lorraine Harper and Amft, {Esther N.} and Neerja Dhaun and Luqmani, {Rashid A.} and Little, {Mark A.} and Jayne, {David R. W.} and Oliver Flossmann and John Mclaren and Vinod Kumar and Erwig, {Lars P.} and Reid, {David M.} and Macfarlane, {Gary J.} and Jones, {Gareth T.}",
    year = "2014",
    doi = "10.1093/rheumatology/ket483",
    language = "English",
    volume = "53",
    pages = "953--956",
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    }

    Basu, N, Mcclean, A, Harper, L, Amft, EN, Dhaun, N, Luqmani, RA, Little, MA, Jayne, DRW, Flossmann, O, Mclaren, J, Kumar, V, Erwig, LP, Reid, DM, Macfarlane, GJ & Jones, GT 2014, 'Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis', Rheumatology, vol. 53, no. 5, pp. 953-956. https://doi.org/10.1093/rheumatology/ket483

    Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis. / Basu, Neil (Lead / Corresponding author); Mcclean, Andrew; Harper, Lorraine; Amft, Esther N.; Dhaun, Neerja; Luqmani, Rashid A.; Little, Mark A.; Jayne, David R. W.; Flossmann, Oliver; Mclaren, John; Kumar, Vinod; Erwig, Lars P.; Reid, David M.; Macfarlane, Gary J.; Jones, Gareth T.

    In: Rheumatology, Vol. 53, No. 5, 2014, p. 953-956.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis

    AU - Basu, Neil

    AU - Mcclean, Andrew

    AU - Harper, Lorraine

    AU - Amft, Esther N.

    AU - Dhaun, Neerja

    AU - Luqmani, Rashid A.

    AU - Little, Mark A.

    AU - Jayne, David R. W.

    AU - Flossmann, Oliver

    AU - Mclaren, John

    AU - Kumar, Vinod

    AU - Erwig, Lars P.

    AU - Reid, David M.

    AU - Macfarlane, Gary J.

    AU - Jones, Gareth T.

    PY - 2014

    Y1 - 2014

    N2 - Objectives: ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work disability is an important outcome for both patient and society that has yet to be fully evaluated in AAV. We aimed to assess employment status in AAV patients and identify putative predictors of their work disability. Methods: A cross-sectional study was undertaken. AAV cases were recruited according to consecutive clinic attendance. Subjects completed a questionnaire that determined employment status and other psychosocial measures. Clinical factors were concurrently recorded by the attending physician. From the data of those subjects of working age, a multivariable model was developed using forward stepwise logistic regression to identify the independent associations of work disability, defined by those subjects reporting unemployment secondary to ill-health. Results are expressed as odds ratios (ORs) and 95% CIs. Results: Of the 410 participants (84.4% response rate), 149 (36.7%) were employed, 197 (48.6%) retired and 54 (13.3%) unemployed secondary to ill health. Of those of working age, 26.0% were considered work disabled. Fatigue (OR 7.1, 95% CI 1.5, 33.1), depression (OR 4.4, 95% CI 1.8, 10.8), severe disease damage [Vasculitis Damage Index (VDI) > 4 (OR 3.9, 95% CI 1.01, 14.7)] and being overweight (OR 3.4, 95% CI 1.3, 8.9) were independently associated with their unemployment. Conclusion: A quarter of working-age AAV subjects reported unemployment as a result of ill health and are characterized by high levels of fatigue, depression, disease damage and being overweight. These potentially modifiable factors may inform future multidisciplinary interventions aimed at alleviating work disability. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

    AB - Objectives: ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by immunotherapeutics, the measurement of other outcomes has become increasingly relevant. Work disability is an important outcome for both patient and society that has yet to be fully evaluated in AAV. We aimed to assess employment status in AAV patients and identify putative predictors of their work disability. Methods: A cross-sectional study was undertaken. AAV cases were recruited according to consecutive clinic attendance. Subjects completed a questionnaire that determined employment status and other psychosocial measures. Clinical factors were concurrently recorded by the attending physician. From the data of those subjects of working age, a multivariable model was developed using forward stepwise logistic regression to identify the independent associations of work disability, defined by those subjects reporting unemployment secondary to ill-health. Results are expressed as odds ratios (ORs) and 95% CIs. Results: Of the 410 participants (84.4% response rate), 149 (36.7%) were employed, 197 (48.6%) retired and 54 (13.3%) unemployed secondary to ill health. Of those of working age, 26.0% were considered work disabled. Fatigue (OR 7.1, 95% CI 1.5, 33.1), depression (OR 4.4, 95% CI 1.8, 10.8), severe disease damage [Vasculitis Damage Index (VDI) > 4 (OR 3.9, 95% CI 1.01, 14.7)] and being overweight (OR 3.4, 95% CI 1.3, 8.9) were independently associated with their unemployment. Conclusion: A quarter of working-age AAV subjects reported unemployment as a result of ill health and are characterized by high levels of fatigue, depression, disease damage and being overweight. These potentially modifiable factors may inform future multidisciplinary interventions aimed at alleviating work disability. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

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    U2 - 10.1093/rheumatology/ket483

    DO - 10.1093/rheumatology/ket483

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    VL - 53

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    EP - 956

    JO - Rheumatology

    JF - Rheumatology

    SN - 1462-0324

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