Markers of senescence?

Philip J Coates

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    The specific identification of cellular senescence in clinical material has important implications for determining the role of senescence in age-related pathologies and in neoplasia in certain tumours. One suggested marker of senescence is the histochemical identification of a specific beta-galactosidase enzyme operative at pH 6.0. However, recent data indicate that this enzyme may not be specific for senescence in all tissues and probably represents the expression of endogenous lysosomal acid beta-galactosidase, which is expressed by a variety of differentiated cell types.
    Original languageEnglish
    Pages (from-to)371-373
    Number of pages3
    JournalJournal of Pathology
    Volume196
    Issue number4
    DOIs
    Publication statusPublished - 2002

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