TY - JOUR
T1 - Maternal and fetal factors which influence cord blood glucose levels in term infants delivered by cesarean section
AU - Koh, Daisy
AU - Hume, Robert
AU - Eisenhofer, Graeme
AU - Ogston, Simon
AU - Watson, Jennifer
AU - Williams, Fiona
PY - 2015/5
Y1 - 2015/5
N2 - Aim: To assess factors contributing to cord venous glucose homeostasis in term infants delivered by elective cesarean section. Methods: Observational study of women-infant pairs at delivery. Biochemical and clinical data were collected about factors which might affect the levels of glucose, lactate, norepinephrine, epinephrine, cortisol, human growth hormone, glucagon, and insulin. Results: In the context of this data-set, three models explained a substantial amount regarding the variation: 79% of the variation in cord glucose levels is explained by levels of maternal glucose, cord venous pH, and cord lactate; 77% of the variation of cord lactate is explained by levels of cord venous pH, valine, maternal lactate and glucose, and cord norepinephrine; and 71% of the variation in cord norepinephrine is explained by levels of cord venous pO2, maternal lactate, cord insulin, cord GABA (gamma-aminobutyric acid), cord lactate, cord epinephrine, cord norepinephrine sulfate, and cord valine. Conclusions: Term infants delivered by cesarean section are relatively hyperinsulinemic (insulin: glucose ratio of 2.4) and glucose levels are strongly associated with maternal glucose levels, cord pO2, and lactate levels. There were no associations with levels of cord glucose and levels of cortisol, epinephrine and lactate, which have been shown to be important contributors to postnatal glucose homeostasis in some infant groups.
AB - Aim: To assess factors contributing to cord venous glucose homeostasis in term infants delivered by elective cesarean section. Methods: Observational study of women-infant pairs at delivery. Biochemical and clinical data were collected about factors which might affect the levels of glucose, lactate, norepinephrine, epinephrine, cortisol, human growth hormone, glucagon, and insulin. Results: In the context of this data-set, three models explained a substantial amount regarding the variation: 79% of the variation in cord glucose levels is explained by levels of maternal glucose, cord venous pH, and cord lactate; 77% of the variation of cord lactate is explained by levels of cord venous pH, valine, maternal lactate and glucose, and cord norepinephrine; and 71% of the variation in cord norepinephrine is explained by levels of cord venous pO2, maternal lactate, cord insulin, cord GABA (gamma-aminobutyric acid), cord lactate, cord epinephrine, cord norepinephrine sulfate, and cord valine. Conclusions: Term infants delivered by cesarean section are relatively hyperinsulinemic (insulin: glucose ratio of 2.4) and glucose levels are strongly associated with maternal glucose levels, cord pO2, and lactate levels. There were no associations with levels of cord glucose and levels of cortisol, epinephrine and lactate, which have been shown to be important contributors to postnatal glucose homeostasis in some infant groups.
KW - Catecholamines
KW - Cesarean section
KW - Glucose homeostasis
KW - Term infants
UR - http://www.scopus.com/inward/record.url?scp=84946150485&partnerID=8YFLogxK
U2 - 10.1515/jpm-2014-0067
DO - 10.1515/jpm-2014-0067
M3 - Article
C2 - 24914709
AN - SCOPUS:84946150485
VL - 43
SP - 339
EP - 346
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
SN - 0300-5577
IS - 3
ER -