Maternal and umbilical cord levels of T4, TSH, TPOAb and TGAb in term infants and neurodevelopmental outcome at 5.5 years.

Fiona L. R. Williams (Lead / Corresponding author), Jennifer Watson, Simon A. Ogston, Theo J. Visser, Robert Hume, Peter Willatts

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Context: Relatively little is known in euthyroid populations about the changes in maternal thyroid hormones during pregnancy, the nature of the relationship to cord thyroid hormone levels, and subsequent infant neurodevelopment.

    Objectives: The aim of the study was to describe the relationship between maternal and cord thyroid hormone parameters and to describe their associations with neurodevelopment at 5.5 years.

    Design: We conducted a follow-up of women and their children born at or over 37 weeks' gestation.

    Main Outcomes: We measured maternal levels of TSH, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), T4, and free T4 (FT4) at 10 and 34 weeks and at delivery, and cord levels of T4, FT4, TPOAb, and TgAb. The association of cord thyroid hormone parameters with McCarthy scale scores adjusted for the major confounders of neurodevelopment.

    Results: Fifteen percent of the women were TPOAb-positive, and 12% were TgAb-positive; the proportion of women with mildly elevated TSH levels increased during pregnancy with the maximum (14%) at delivery. Lower perceptual performance and motor scores were found with TgAb-positive women and lower perceptual performance scores with TgAb-positive cord levels; otherwise, unadjusted maternal levels of TPOAb, TgAb, and TSH and unadjusted cord levels of FT4, TPOAb, and TgAb were not associated with neurodevelopment at 5.5 years. Low cord T4 levels were associated with significant increments in four McCarthy scales: General Cognitive Index, Verbal, Quantitative, and Memory scales—increments that persisted after adjustment at 11.4, 7.8, 7.6, and 7.8 points, respectively.

    Conclusions: Lower levels of cord T4 were associated with increments in the McCarthy scales in the domains that tested cognitive and verbal abilities at 5.5 years.
    Original languageEnglish
    Pages (from-to)829-838
    Number of pages10
    JournalJournal of Clinical Endocrinology and Metabolism
    Volume98
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2013

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    Iodide Peroxidase
    Umbilical Cord
    Mothers
    Thyroglobulin
    Antibodies
    Thyroid Hormones
    Pregnancy
    Psychomotor Performance
    Social Adjustment
    Aptitude

    Cite this

    Williams, Fiona L. R. ; Watson, Jennifer ; Ogston, Simon A. ; Visser, Theo J. ; Hume, Robert ; Willatts, Peter. / Maternal and umbilical cord levels of T4, TSH, TPOAb and TGAb in term infants and neurodevelopmental outcome at 5.5 years. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 2. pp. 829-838.
    @article{de6644fdc4dc41fba6027ab083292180,
    title = "Maternal and umbilical cord levels of T4, TSH, TPOAb and TGAb in term infants and neurodevelopmental outcome at 5.5 years.",
    abstract = "Context: Relatively little is known in euthyroid populations about the changes in maternal thyroid hormones during pregnancy, the nature of the relationship to cord thyroid hormone levels, and subsequent infant neurodevelopment.Objectives: The aim of the study was to describe the relationship between maternal and cord thyroid hormone parameters and to describe their associations with neurodevelopment at 5.5 years.Design: We conducted a follow-up of women and their children born at or over 37 weeks' gestation.Main Outcomes: We measured maternal levels of TSH, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), T4, and free T4 (FT4) at 10 and 34 weeks and at delivery, and cord levels of T4, FT4, TPOAb, and TgAb. The association of cord thyroid hormone parameters with McCarthy scale scores adjusted for the major confounders of neurodevelopment.Results: Fifteen percent of the women were TPOAb-positive, and 12{\%} were TgAb-positive; the proportion of women with mildly elevated TSH levels increased during pregnancy with the maximum (14{\%}) at delivery. Lower perceptual performance and motor scores were found with TgAb-positive women and lower perceptual performance scores with TgAb-positive cord levels; otherwise, unadjusted maternal levels of TPOAb, TgAb, and TSH and unadjusted cord levels of FT4, TPOAb, and TgAb were not associated with neurodevelopment at 5.5 years. Low cord T4 levels were associated with significant increments in four McCarthy scales: General Cognitive Index, Verbal, Quantitative, and Memory scales—increments that persisted after adjustment at 11.4, 7.8, 7.6, and 7.8 points, respectively.Conclusions: Lower levels of cord T4 were associated with increments in the McCarthy scales in the domains that tested cognitive and verbal abilities at 5.5 years.",
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    year = "2013",
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    doi = "10.1210/jc.2012-3572",
    language = "English",
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    Maternal and umbilical cord levels of T4, TSH, TPOAb and TGAb in term infants and neurodevelopmental outcome at 5.5 years. / Williams, Fiona L. R. (Lead / Corresponding author); Watson, Jennifer; Ogston, Simon A.; Visser, Theo J.; Hume, Robert; Willatts, Peter.

    In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 01.02.2013, p. 829-838.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Maternal and umbilical cord levels of T4, TSH, TPOAb and TGAb in term infants and neurodevelopmental outcome at 5.5 years.

    AU - Williams, Fiona L. R.

    AU - Watson, Jennifer

    AU - Ogston, Simon A.

    AU - Visser, Theo J.

    AU - Hume, Robert

    AU - Willatts, Peter

    PY - 2013/2/1

    Y1 - 2013/2/1

    N2 - Context: Relatively little is known in euthyroid populations about the changes in maternal thyroid hormones during pregnancy, the nature of the relationship to cord thyroid hormone levels, and subsequent infant neurodevelopment.Objectives: The aim of the study was to describe the relationship between maternal and cord thyroid hormone parameters and to describe their associations with neurodevelopment at 5.5 years.Design: We conducted a follow-up of women and their children born at or over 37 weeks' gestation.Main Outcomes: We measured maternal levels of TSH, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), T4, and free T4 (FT4) at 10 and 34 weeks and at delivery, and cord levels of T4, FT4, TPOAb, and TgAb. The association of cord thyroid hormone parameters with McCarthy scale scores adjusted for the major confounders of neurodevelopment.Results: Fifteen percent of the women were TPOAb-positive, and 12% were TgAb-positive; the proportion of women with mildly elevated TSH levels increased during pregnancy with the maximum (14%) at delivery. Lower perceptual performance and motor scores were found with TgAb-positive women and lower perceptual performance scores with TgAb-positive cord levels; otherwise, unadjusted maternal levels of TPOAb, TgAb, and TSH and unadjusted cord levels of FT4, TPOAb, and TgAb were not associated with neurodevelopment at 5.5 years. Low cord T4 levels were associated with significant increments in four McCarthy scales: General Cognitive Index, Verbal, Quantitative, and Memory scales—increments that persisted after adjustment at 11.4, 7.8, 7.6, and 7.8 points, respectively.Conclusions: Lower levels of cord T4 were associated with increments in the McCarthy scales in the domains that tested cognitive and verbal abilities at 5.5 years.

    AB - Context: Relatively little is known in euthyroid populations about the changes in maternal thyroid hormones during pregnancy, the nature of the relationship to cord thyroid hormone levels, and subsequent infant neurodevelopment.Objectives: The aim of the study was to describe the relationship between maternal and cord thyroid hormone parameters and to describe their associations with neurodevelopment at 5.5 years.Design: We conducted a follow-up of women and their children born at or over 37 weeks' gestation.Main Outcomes: We measured maternal levels of TSH, thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), T4, and free T4 (FT4) at 10 and 34 weeks and at delivery, and cord levels of T4, FT4, TPOAb, and TgAb. The association of cord thyroid hormone parameters with McCarthy scale scores adjusted for the major confounders of neurodevelopment.Results: Fifteen percent of the women were TPOAb-positive, and 12% were TgAb-positive; the proportion of women with mildly elevated TSH levels increased during pregnancy with the maximum (14%) at delivery. Lower perceptual performance and motor scores were found with TgAb-positive women and lower perceptual performance scores with TgAb-positive cord levels; otherwise, unadjusted maternal levels of TPOAb, TgAb, and TSH and unadjusted cord levels of FT4, TPOAb, and TgAb were not associated with neurodevelopment at 5.5 years. Low cord T4 levels were associated with significant increments in four McCarthy scales: General Cognitive Index, Verbal, Quantitative, and Memory scales—increments that persisted after adjustment at 11.4, 7.8, 7.6, and 7.8 points, respectively.Conclusions: Lower levels of cord T4 were associated with increments in the McCarthy scales in the domains that tested cognitive and verbal abilities at 5.5 years.

    U2 - 10.1210/jc.2012-3572

    DO - 10.1210/jc.2012-3572

    M3 - Article

    VL - 98

    SP - 829

    EP - 838

    JO - Journal of Clinical Endocrinology and Metabolism

    JF - Journal of Clinical Endocrinology and Metabolism

    SN - 0021-972X

    IS - 2

    ER -