Mathematical modelling of cancer invasion of tissue: the role and effect of nonlocal interactions

Zuzanna Szymanska, Cristian Morales Rodrigo, Miroslaw Lachowicz, Mark A. J. Chaplain

    Research output: Contribution to journalArticlepeer-review

    92 Citations (Scopus)

    Abstract

    In this paper we consider a mathematical model of cancer cell invasion of tissue (extracellular matrix). Two crucial components of tissue invasion are (i) cancer cell proliferation, and (ii) over-expression and secretion of proteolytic enzymes by the cancer cells. The proteolytic enzymes are responsible for the degradation of the tissue, enabling the proliferating cancer cells to actively invade and migrate into the degraded tissue. Our model focuses on the role of nonlocal kinetic terms modelling competition for space and degradation. The model consists of a system of reaction-diffusion-taxis partial differential equations, with nonlocal (integral) terms describing the interactions between cancer cells and the host tissue. First of all we prove results concerning the local existence, uniqueness and regularity of solutions. We then prove global existence. Using Green's functions, we transform our original nonlocal equations into a coupled system of parabolic and elliptic equations and we undertake a numerical analysis of this equivalent system, presenting computational simulation results from our model showing the effect of the nonlocal terms (travelling waves we observed have the shape closely linked to the nonlocal terms). Finally, in the discussion section, concluding remarks are made and open problems are indicated.

    Original languageEnglish
    Pages (from-to)257-281
    Number of pages25
    JournalMathematical Models and Methods in Applied Sciences
    Volume19
    Issue number2
    DOIs
    Publication statusPublished - Feb 2009

    Keywords

    • Cancer invasion of tissue
    • Haptotaxis
    • Nonlocal interactions
    • Existence
    • Uniqueness
    • Regularity of solutions
    • Computational simulations
    • Travelling waves
    • Reaction-diffusion equations
    • Cell migration
    • Melanoma cells
    • Tumor cells
    • Motility
    • Chemotaxis
    • Angiogenesis
    • Adhesion

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