TY - JOUR
T1 - Maximizing Success
T2 - An Overview of Optimizing the Ovarian Tissue Transplantation Site
AU - Saçıntı, Koray Görkem
AU - Sadat, Rowaida
AU - Özkavukçu, Sinan
AU - Sonmezer, Meltem
AU - Sönmezer, Murat
N1 - Publisher Copyright:
© 2024, SBRA - Associação Brasileira de Reprodução Assistida (Brazilian Society of Assisted Reproduction). All rights reserved.
PY - 2024/8/26
Y1 - 2024/8/26
N2 - Ovarian tissue cryopreservation and transplantation (OTCT) has emerged in recent years as a potential method for reversing abnormal endocrine and reproductive functions, particularly in patients receiving gonadotoxic cancer treatments having longer survival rates. From its first rodent experiments to human trials, OTCT has evolved tremendously, opening new windows for further utilization. Since then, significant progress has been achieved in terms of techniques used for surgical removal of the tissue, optimal fragment size, freezing and thawing procedures, and appropriate surgical sites for the subsequent reimplementation of the graft. In addition, various approaches have been proposed to decrease the risk of ischemic injury, which is the leading cause of significant follicle loss during neo-angiogenesis. This review aims to discuss the pros and cons of ovarian and retroperitoneal transplantation sites, highlighting the justifications for the viability and efficacy of different transplantation sites as well as the potential advantages and drawbacks of retroperitoneal or preperitoneal area.
AB - Ovarian tissue cryopreservation and transplantation (OTCT) has emerged in recent years as a potential method for reversing abnormal endocrine and reproductive functions, particularly in patients receiving gonadotoxic cancer treatments having longer survival rates. From its first rodent experiments to human trials, OTCT has evolved tremendously, opening new windows for further utilization. Since then, significant progress has been achieved in terms of techniques used for surgical removal of the tissue, optimal fragment size, freezing and thawing procedures, and appropriate surgical sites for the subsequent reimplementation of the graft. In addition, various approaches have been proposed to decrease the risk of ischemic injury, which is the leading cause of significant follicle loss during neo-angiogenesis. This review aims to discuss the pros and cons of ovarian and retroperitoneal transplantation sites, highlighting the justifications for the viability and efficacy of different transplantation sites as well as the potential advantages and drawbacks of retroperitoneal or preperitoneal area.
KW - ovarian tissue cryopreservation
KW - ovarian tissue transplantation
KW - retroperitoneum
KW - transplantation site
U2 - 10.5935/1518-0557.20240027
DO - 10.5935/1518-0557.20240027
M3 - Review article
C2 - 38838161
AN - SCOPUS:85202301695
SN - 1517-5693
VL - 28
SP - 497
EP - 502
JO - Jornal Brasileiro de Reproducao Assistida
JF - Jornal Brasileiro de Reproducao Assistida
IS - 3
ER -