Measurement of proton resonance frequency shift coefficient during MR-guided focused ultrasound on Thiel embalmed tissue

Ioannis Karakitsios (Lead / Corresponding author), Osnat Dogadkin, Nhan Le, Andreas Melzer

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Purpose: To estimate the value of proton resonance frequency (PRF) shift coefficient of explanted Thiel embalmed animal and human tissue used as a preclinical model for treatment with MR-guided focused ultrasound (FUS). Methods: Thiel embalmed human liver, ovine liver, and porcine muscle were heated using two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue to obtain a series of phase difference, ?F, maps. A fiber-optic thermocouple was inserted in the tissue to measure the temperature difference, ?T. The PRF shift coefficient was calculated from the measured ?F, ?T. Results: In the case of bulk heating, the mean values (±SD) of the PRF coefficient for Thiel embalmed ovine liver, porcine muscle, and human liver were: 0.017 (5 × 10-4) ppm/°C, 0.015 (6 × 10-4) ppm/°C, and 0.012 (6 × 10-4) ppm/°C, respectively. Similar values were found in tissues heated with FUS. Conclusion: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue, suggesting that embalming a tissue with Thiel fluid can affect PRF thermometry. The chemical composition of the Thiel fluid and the electrical conductivity may explain these results. © 2014 Wiley Periodicals, Inc.
    Original languageEnglish
    Pages (from-to)260-265
    Number of pages6
    JournalMagnetic Resonance in Medicine
    Volume74
    Issue number1
    Early online date23 Jul 2014
    DOIs
    Publication statusPublished - Jul 2015

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    Protons
    Thermometry
    Heating
    Liver
    Sheep
    Embalming
    Swine
    Myelinated Nerve Fibers
    Muscles
    Electric Conductivity
    Temperature

    Cite this

    @article{d15822bfed624584924381586a5f95e9,
    title = "Measurement of proton resonance frequency shift coefficient during MR-guided focused ultrasound on Thiel embalmed tissue",
    abstract = "Purpose: To estimate the value of proton resonance frequency (PRF) shift coefficient of explanted Thiel embalmed animal and human tissue used as a preclinical model for treatment with MR-guided focused ultrasound (FUS). Methods: Thiel embalmed human liver, ovine liver, and porcine muscle were heated using two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue to obtain a series of phase difference, ?F, maps. A fiber-optic thermocouple was inserted in the tissue to measure the temperature difference, ?T. The PRF shift coefficient was calculated from the measured ?F, ?T. Results: In the case of bulk heating, the mean values (±SD) of the PRF coefficient for Thiel embalmed ovine liver, porcine muscle, and human liver were: 0.017 (5 × 10-4) ppm/°C, 0.015 (6 × 10-4) ppm/°C, and 0.012 (6 × 10-4) ppm/°C, respectively. Similar values were found in tissues heated with FUS. Conclusion: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue, suggesting that embalming a tissue with Thiel fluid can affect PRF thermometry. The chemical composition of the Thiel fluid and the electrical conductivity may explain these results. {\circledC} 2014 Wiley Periodicals, Inc.",
    author = "Ioannis Karakitsios and Osnat Dogadkin and Nhan Le and Andreas Melzer",
    note = "Copyright {\circledC} 2014 Wiley Periodicals, Inc.",
    year = "2015",
    month = "7",
    doi = "10.1002/mrm.25378",
    language = "English",
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    }

    Measurement of proton resonance frequency shift coefficient during MR-guided focused ultrasound on Thiel embalmed tissue. / Karakitsios, Ioannis (Lead / Corresponding author); Dogadkin, Osnat; Le, Nhan; Melzer, Andreas.

    In: Magnetic Resonance in Medicine , Vol. 74, No. 1, 07.2015, p. 260-265.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Measurement of proton resonance frequency shift coefficient during MR-guided focused ultrasound on Thiel embalmed tissue

    AU - Karakitsios, Ioannis

    AU - Dogadkin, Osnat

    AU - Le, Nhan

    AU - Melzer, Andreas

    N1 - Copyright © 2014 Wiley Periodicals, Inc.

    PY - 2015/7

    Y1 - 2015/7

    N2 - Purpose: To estimate the value of proton resonance frequency (PRF) shift coefficient of explanted Thiel embalmed animal and human tissue used as a preclinical model for treatment with MR-guided focused ultrasound (FUS). Methods: Thiel embalmed human liver, ovine liver, and porcine muscle were heated using two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue to obtain a series of phase difference, ?F, maps. A fiber-optic thermocouple was inserted in the tissue to measure the temperature difference, ?T. The PRF shift coefficient was calculated from the measured ?F, ?T. Results: In the case of bulk heating, the mean values (±SD) of the PRF coefficient for Thiel embalmed ovine liver, porcine muscle, and human liver were: 0.017 (5 × 10-4) ppm/°C, 0.015 (6 × 10-4) ppm/°C, and 0.012 (6 × 10-4) ppm/°C, respectively. Similar values were found in tissues heated with FUS. Conclusion: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue, suggesting that embalming a tissue with Thiel fluid can affect PRF thermometry. The chemical composition of the Thiel fluid and the electrical conductivity may explain these results. © 2014 Wiley Periodicals, Inc.

    AB - Purpose: To estimate the value of proton resonance frequency (PRF) shift coefficient of explanted Thiel embalmed animal and human tissue used as a preclinical model for treatment with MR-guided focused ultrasound (FUS). Methods: Thiel embalmed human liver, ovine liver, and porcine muscle were heated using two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue to obtain a series of phase difference, ?F, maps. A fiber-optic thermocouple was inserted in the tissue to measure the temperature difference, ?T. The PRF shift coefficient was calculated from the measured ?F, ?T. Results: In the case of bulk heating, the mean values (±SD) of the PRF coefficient for Thiel embalmed ovine liver, porcine muscle, and human liver were: 0.017 (5 × 10-4) ppm/°C, 0.015 (6 × 10-4) ppm/°C, and 0.012 (6 × 10-4) ppm/°C, respectively. Similar values were found in tissues heated with FUS. Conclusion: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue, suggesting that embalming a tissue with Thiel fluid can affect PRF thermometry. The chemical composition of the Thiel fluid and the electrical conductivity may explain these results. © 2014 Wiley Periodicals, Inc.

    U2 - 10.1002/mrm.25378

    DO - 10.1002/mrm.25378

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    ER -