Abstract
Purpose: To estimate the value of proton resonance frequency (PRF) shift coefficient of explanted Thiel embalmed animal and human tissue used as a preclinical model for treatment with MR-guided focused ultrasound (FUS). Methods: Thiel embalmed human liver, ovine liver, and porcine muscle were heated using two methods: bulk heating and FUS-induced heating. Phase-referenced PRF thermometry was applied during cooling of the tissue to obtain a series of phase difference, ?F, maps. A fiber-optic thermocouple was inserted in the tissue to measure the temperature difference, ?T. The PRF shift coefficient was calculated from the measured ?F, ?T. Results: In the case of bulk heating, the mean values (±SD) of the PRF coefficient for Thiel embalmed ovine liver, porcine muscle, and human liver were: 0.017 (5 × 10-4) ppm/°C, 0.015 (6 × 10-4) ppm/°C, and 0.012 (6 × 10-4) ppm/°C, respectively. Similar values were found in tissues heated with FUS. Conclusion: The values of PRF coefficient measured for the Thiel embalmed tissue were higher than the values for fresh tissue, suggesting that embalming a tissue with Thiel fluid can affect PRF thermometry. The chemical composition of the Thiel fluid and the electrical conductivity may explain these results. © 2014 Wiley Periodicals, Inc.
Original language | English |
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Pages (from-to) | 260-265 |
Number of pages | 6 |
Journal | Magnetic Resonance in Medicine |
Volume | 74 |
Issue number | 1 |
Early online date | 23 Jul 2014 |
DOIs | |
Publication status | Published - Jul 2015 |
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Dive into the research topics of 'Measurement of proton resonance frequency shift coefficient during MR-guided focused ultrasound on Thiel embalmed tissue'. Together they form a unique fingerprint.Student theses
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Shear-wave imaging guidance for high-intensity focused ultrasound therapy
Le, M. (Author), Huang, Z. (Supervisor) & Nabi, G. (Supervisor), 2019Student thesis: Doctoral Thesis › Doctor of Philosophy
Profiles
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Melzer, Andreas
- Neuroscience - Professor and Director of IMSAT (Teaching and Research)
Person: Academic