Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

Ross T. Aitchison; Laura Ward; Graeme J. Kennedy; Xinhua Shu; David C. Mansfield; Uma Shahani

doi:10.1007/s00592-018-1200-5

Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

Ross T. Aitchison (Lead / Corresponding author), Laura Ward, Graeme J. Kennedy, Xinhua Shu, David C. Mansfield, Uma Shahani

Health and Clinical Services

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

13 Downloads (Pure)

Abstract

Aims: Diabetes mellitus affects about 6% of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.

Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA_1c) level (± SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ± 0.4% in the non-diabetic group. Raw haemodynamic data were normalised to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.

Results: There were statistically significant differences in ∆[HbO] and ∆[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type 1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type 2 counterparts. There was also a linear relationship between both ∆[HbO] and ∆[HbR] as a function of HbA_1c level (p < 0.0005).

Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ∆[HbO] and decrease in ∆[HbR] appears to be correlated with HbA_1c level.

Original language	English
Pages (from-to)	1181-1189
Number of pages	9
Journal	Acta Diabetologica
Volume	55
Issue number	11
Early online date	6 Aug 2018
DOIs	https://doi.org/10.1007/s00592-018-1200-5
Publication status	Published - Nov 2018

Keywords

Autonomic dysfunction
Diabetes
Functional near-infrared spectroscopy
Haemodynamic response
Visual cortex

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00592-018-1200-5Licence: CC BY

Final Published VersionFinal published version, 1.32 MBLicence: CC BY

Cite this

@article{1c0b7851654e4bddad291db4c524407d,

title = "Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy",

abstract = "Aims: Diabetes mellitus affects about 6% of the world{\textquoteright}s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants{\textquoteright} mean glycated haemoglobin (HbA1c) level (± SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ± 0.4% in the non-diabetic group. Raw haemodynamic data were normalised to baseline, and the last 15 s of data from each {\textquoteleft}stimulus on{\textquoteright} and {\textquoteleft}stimulus off{\textquoteright} condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ∆[HbO] and ∆[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type 1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type 2 counterparts. There was also a linear relationship between both ∆[HbO] and ∆[HbR] as a function of HbA1c level (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ∆[HbO] and decrease in ∆[HbR] appears to be correlated with HbA1c level.",

keywords = "Autonomic dysfunction, Diabetes, Functional near-infrared spectroscopy, Haemodynamic response, Visual cortex",

author = "Aitchison, {Ross T.} and Laura Ward and Kennedy, {Graeme J.} and Xinhua Shu and Mansfield, {David C.} and Uma Shahani",

note = "Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = nov,

doi = "10.1007/s00592-018-1200-5",

language = "English",

volume = "55",

pages = "1181--1189",

journal = "Acta Diabetologica",

issn = "0940-5429",

publisher = "Springer Verlag",

number = "11",

}

TY - JOUR

T1 - Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

AU - Aitchison, Ross T.

AU - Ward, Laura

AU - Kennedy, Graeme J.

AU - Shu, Xinhua

AU - Mansfield, David C.

AU - Shahani, Uma

PY - 2018/11

Y1 - 2018/11

N2 - Aims: Diabetes mellitus affects about 6% of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA1c) level (± SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ± 0.4% in the non-diabetic group. Raw haemodynamic data were normalised to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ∆[HbO] and ∆[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type 1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type 2 counterparts. There was also a linear relationship between both ∆[HbO] and ∆[HbR] as a function of HbA1c level (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ∆[HbO] and decrease in ∆[HbR] appears to be correlated with HbA1c level.

AB - Aims: Diabetes mellitus affects about 6% of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA1c) level (± SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ± 0.4% in the non-diabetic group. Raw haemodynamic data were normalised to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ∆[HbO] and ∆[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type 1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type 2 counterparts. There was also a linear relationship between both ∆[HbO] and ∆[HbR] as a function of HbA1c level (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ∆[HbO] and decrease in ∆[HbR] appears to be correlated with HbA1c level.

KW - Autonomic dysfunction

KW - Diabetes

KW - Functional near-infrared spectroscopy

KW - Haemodynamic response

KW - Visual cortex

UR - http://www.scopus.com/inward/record.url?scp=85051694642&partnerID=8YFLogxK

U2 - 10.1007/s00592-018-1200-5

DO - 10.1007/s00592-018-1200-5

M3 - Article

C2 - 30083981

AN - SCOPUS:85051694642

SN - 0940-5429

VL - 55

SP - 1181

EP - 1189

JO - Acta Diabetologica

JF - Acta Diabetologica

IS - 11

ER -

Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this