Mechanism of activation and function of protein kinase B

    Research output: Contribution to journalReview article

    655 Citations (Scopus)


    The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.

    Original languageEnglish
    Pages (from-to)55-62
    Number of pages8
    JournalCurrent Opinion in Genetics and Development
    Issue number1
    Publication statusPublished - 1 Feb 1998

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