Mechanism of activation and function of protein kinase B

Dario R. Alessi; Philip Cohen

doi:10.1016/S0959-437X(98)80062-2

Mechanism of activation and function of protein kinase B

Dario R. Alessi, Philip Cohen

Research output: Contribution to journal › Review article › peer-review

685 Citations (Scopus)

Abstract

The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.

Original language	English
Pages (from-to)	55-62
Number of pages	8
Journal	Current Opinion in Genetics and Development
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S0959-437X(98)80062-2
Publication status	Published - 1 Feb 1998

ASJC Scopus subject areas

Genetics
Developmental Biology

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title = "Mechanism of activation and function of protein kinase B",

abstract = "The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.",

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AB - The past year has seen significant advances in our understanding of how protein kinase B (PKB) is activated and of the central role it plays in insulin signalling and in mediating the protective effects of survival factors against apoptosis. The highlights include the discovery of a protein kinase required for the 3-phosphoinositide-dependent activation of PKB and the identification of several physiological substrates for PKB.

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Mechanism of activation and function of protein kinase B

Abstract

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