Mechanism of transcriptional activation by the Myc oncoproteins

Victoria H. Cowling, Michael D. Cole

    Research output: Contribution to journalReview articlepeer-review

    133 Citations (Scopus)

    Abstract

    The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.
    Original languageEnglish
    Pages (from-to)242-52
    Number of pages11
    JournalSeminars in Cancer Biology
    Volume16
    Issue number4
    DOIs
    Publication statusPublished - 2006

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