Abstract
The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.
| Original language | English |
|---|---|
| Pages (from-to) | 242-52 |
| Number of pages | 11 |
| Journal | Seminars in Cancer Biology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 |