Mechanism of transcriptional activation by the Myc oncoproteins

TY - JOUR

T1 - Mechanism of transcriptional activation by the Myc oncoproteins

AU - Cowling, Victoria H.

AU - Cole, Michael D.

PY - 2006

Y1 - 2006

N2 - The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.

AB - The Myc family proteins are potent oncogenes that can activate and repress a very large number of cellular target genes. The amino terminus of Myc contains a transactivation domain that can recruit a number of nuclear cofactors with diverse activities. Functional studies link transactivation to the ability of Myc to promote normal cell proliferation and for oncogenic transformation. The biochemical mechanism of Myc-mediated transactivation has revealed a wide range of effects on chromatin and basal transcription. This review summarizes recent advances in understanding the function of Myc as a transcriptional activator and the role of this activity in Myc biological activities.

U2 - 10.1016/j.semcancer.2006.08.001

DO - 10.1016/j.semcancer.2006.08.001

M3 - Review article

C2 - 16935524

SN - 1044-579X

VL - 16

SP - 242

EP - 252

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 4

ER -