Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

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    Abstract

    Chromatin provides both a means to accommodate a large amount of genetic material in a small space and a means to package the same genetic material in different chromatin states. Transitions between chromatin states are enabled by chromatin-remodeling ATPases, which catalyze a diverse range of structural transformations. Biochemical evidence over the last two decades suggests that chromatin-remodeling activities may have emerged by adaptation of ancient DNA translocases to respond to specific features of chromatin. Here, we discuss such evidence and also relate mechanistic insights to our understanding of how chromatin-remodeling enzymes enable different in vivo processes.
    Original languageEnglish
    Pages (from-to)490-503
    Number of pages14
    JournalCell
    Volume154
    Issue number3
    DOIs
    Publication statusPublished - 2013

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