Projects per year
Chromatin provides both a means to accommodate a large amount of genetic material in a small space and a means to package the same genetic material in different chromatin states. Transitions between chromatin states are enabled by chromatin-remodeling ATPases, which catalyze a diverse range of structural transformations. Biochemical evidence over the last two decades suggests that chromatin-remodeling activities may have emerged by adaptation of ancient DNA translocases to respond to specific features of chromatin. Here, we discuss such evidence and also relate mechanistic insights to our understanding of how chromatin-remodeling enzymes enable different in vivo processes.
|Number of pages||14|
|Publication status||Published - 2013|
FingerprintDive into the research topics of 'Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes'. Together they form a unique fingerprint.
- 2 Finished
Strategic Award: Wellcome Trust Technology Platform
Blow, J., Lamond, A. & Owen-Hughes, T.
1/01/13 → 30/09/18
Mechanisms for Remodelling Chromatin (Senior Fellowship Renewal)
1/01/12 → 31/05/19