Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

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• Finished

  The Spatiotemporal Regulation of the Keap1/Nrf2 Pathway (Joint with University College London)

  Dinkova-Kostova, A.

  Biotechnology and Biological Sciences Research Council

  30/09/14 → 27/02/18

  Project: Research

  • Kelch-Like ECH-Associated Protein 1 100%
  • Cytoprotective 39%
  • Oxidation-Reduction 35%
  • NF-E2-Related Factor 2 35%
  • Protein 33%

• Pivotal Role of the Keap1-Nrf2 Pathway in the Pathogenesis and Prevention of Non Alcoholic Steatohepatitis Induced Cirrhosis

  Ashford, M., Dillon, J., Hayes, J. & McCrimmon, R.

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • NF-E2-Related Factor 2 100%
  • Non-alcoholic Fatty Liver Disease 50%
  • Fatty Liver 48%
  • TBE 31 45%
  • Oxidative Stress 38%

• Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases

  Ashford, M., Dillon, J., Hayes, J., McCrimmon, R. & Trost, M.

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • NF-E2-Related Factor 2 100%
  • Non-alcoholic Fatty Liver Disease 50%
  • Fatty Liver 48%
  • TBE 31 45%
  • Oxidative Stress 38%