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It has been demonstrated that Ag-TiO2 nanocomposite coatings with excellent antimicrobial activity and biocompatibility have potential to reduce infection problems. However, the mechanism of the synergistic effect of Ag-TiO2 coatings on antibacterial efficiency is still not well understood. In this study, five types of Ag-TiO2 nanocomposited coatings with different TiO2 contents were prepared on titanium substrate. The leaching tests indicated that the incorporation of TiO2 nano-particles into Ag matrix significantly promoted Ag ion release. The surface energy measurements showed that the addition of TiO2 nano-particles also significantly increased the electron donor surface energy of the coatings. The bacterial adhesion assays with Escherichia coli and Staphylococcus aureus demonstrated that the number of adhered bacteria decreased with increasing the electron donor surface energy. The increased Ag ion release rate and the increased electron donor surface energy contributed to an enhanced antibacterial efficiency of the coatings.
- Bacterial adhesion
- surface energy
- medical implants
- Anti-Bacterial Agents/pharmacology
- Escherichia coli/drug effects
- Staphylococcus aureus/drug effects
- Surface Properties
- Drug Liberation
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- 1 Finished
1/12/16 → 31/10/21