Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO2 Coatings

Chen Liu; Lei Geng; YiFan Yu; Yutong Zhang; Buyun Zhao; Qi Zhao

doi:10.1080/08927014.2017.1423287

Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO₂ Coatings

Chen Liu, Lei Geng, YiFan Yu, Yutong Zhang, Buyun Zhao, Qi Zhao (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

325 Downloads (Pure)

Abstract

It has been demonstrated that Ag-TiO2 nanocomposite coatings with excellent antimicrobial activity and biocompatibility have potential to reduce infection problems. However, the mechanism of the synergistic effect of Ag-TiO2 coatings on antibacterial efficiency is still not well understood. In this study, five types of Ag-TiO2 nanocomposited coatings with different TiO2 contents were prepared on titanium substrate. The leaching tests indicated that the incorporation of TiO2 nano-particles into Ag matrix significantly promoted Ag ion release. The surface energy measurements showed that the addition of TiO2 nano-particles also significantly increased the electron donor surface energy of the coatings. The bacterial adhesion assays with Escherichia coli and Staphylococcus aureus demonstrated that the number of adhered bacteria decreased with increasing the electron donor surface energy. The increased Ag ion release rate and the increased electron donor surface energy contributed to an enhanced antibacterial efficiency of the coatings.

Original language	English
Pages (from-to)	190-199
Number of pages	10
Journal	Biofouling
Volume	34
Issue number	2
Early online date	29 Jan 2018
DOIs	https://doi.org/10.1080/08927014.2017.1423287
Publication status	Published - 7 Feb 2018

Keywords

Bacterial adhesion
surface energy
coatings
medical implants
infection
Silver/pharmacology
Anti-Bacterial Agents/pharmacology
Escherichia coli/drug effects
Titanium/pharmacology
Staphylococcus aureus/drug effects
Surface Properties
Drug Liberation
Nanocomposites/chemistry

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Water Science and Technology
Aquatic Science

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10.1080/08927014.2017.1423287Licence: CC BY

Final Published VersionFinal published version, 4.05 MBLicence: CC BY

Cite this

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title = "Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO2 Coatings",

abstract = "It has been demonstrated that Ag-TiO2 nanocomposite coatings with excellent antimicrobial activity and biocompatibility have potential to reduce infection problems. However, the mechanism of the synergistic effect of Ag-TiO2 coatings on antibacterial efficiency is still not well understood. In this study, five types of Ag-TiO2 nanocomposited coatings with different TiO2 contents were prepared on titanium substrate. The leaching tests indicated that the incorporation of TiO2 nano-particles into Ag matrix significantly promoted Ag ion release. The surface energy measurements showed that the addition of TiO2 nano-particles also significantly increased the electron donor surface energy of the coatings. The bacterial adhesion assays with Escherichia coli and Staphylococcus aureus demonstrated that the number of adhered bacteria decreased with increasing the electron donor surface energy. The increased Ag ion release rate and the increased electron donor surface energy contributed to an enhanced antibacterial efficiency of the coatings. ",

keywords = "Bacterial adhesion, surface energy, coatings, medical implants, infection, Silver/pharmacology, Anti-Bacterial Agents/pharmacology, Escherichia coli/drug effects, Titanium/pharmacology, Staphylococcus aureus/drug effects, Surface Properties, Drug Liberation, Nanocomposites/chemistry",

author = "Chen Liu and Lei Geng and YiFan Yu and Yutong Zhang and Buyun Zhao and Qi Zhao",

note = "Financial supports from the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201510025008), the National Nature Science Foundation of China (51701131), the Internal Exchange Training of Teacher (07001160950171) and the UK Engineering and Physical Sciences Research Council (EP/P00301X/1) are acknowledged.",

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doi = "10.1080/08927014.2017.1423287",

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AU - Liu, Chen

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AU - Yu, YiFan

AU - Zhang, Yutong

AU - Zhao, Buyun

AU - Zhao, Qi

N1 - Financial supports from the Scientific Research Common Program of Beijing Municipal Commission of Education (Grant No. KM201510025008), the National Nature Science Foundation of China (51701131), the Internal Exchange Training of Teacher (07001160950171) and the UK Engineering and Physical Sciences Research Council (EP/P00301X/1) are acknowledged.

PY - 2018/2/7

Y1 - 2018/2/7

N2 - It has been demonstrated that Ag-TiO2 nanocomposite coatings with excellent antimicrobial activity and biocompatibility have potential to reduce infection problems. However, the mechanism of the synergistic effect of Ag-TiO2 coatings on antibacterial efficiency is still not well understood. In this study, five types of Ag-TiO2 nanocomposited coatings with different TiO2 contents were prepared on titanium substrate. The leaching tests indicated that the incorporation of TiO2 nano-particles into Ag matrix significantly promoted Ag ion release. The surface energy measurements showed that the addition of TiO2 nano-particles also significantly increased the electron donor surface energy of the coatings. The bacterial adhesion assays with Escherichia coli and Staphylococcus aureus demonstrated that the number of adhered bacteria decreased with increasing the electron donor surface energy. The increased Ag ion release rate and the increased electron donor surface energy contributed to an enhanced antibacterial efficiency of the coatings.

AB - It has been demonstrated that Ag-TiO2 nanocomposite coatings with excellent antimicrobial activity and biocompatibility have potential to reduce infection problems. However, the mechanism of the synergistic effect of Ag-TiO2 coatings on antibacterial efficiency is still not well understood. In this study, five types of Ag-TiO2 nanocomposited coatings with different TiO2 contents were prepared on titanium substrate. The leaching tests indicated that the incorporation of TiO2 nano-particles into Ag matrix significantly promoted Ag ion release. The surface energy measurements showed that the addition of TiO2 nano-particles also significantly increased the electron donor surface energy of the coatings. The bacterial adhesion assays with Escherichia coli and Staphylococcus aureus demonstrated that the number of adhered bacteria decreased with increasing the electron donor surface energy. The increased Ag ion release rate and the increased electron donor surface energy contributed to an enhanced antibacterial efficiency of the coatings.

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Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO₂ Coatings

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Keywords

ASJC Scopus subject areas

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Influence of Surface Properties of New Biomaterials for Catheters on Bacterial Adhesion Urine

Zhao, Qi

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Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO2 Coatings

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ASJC Scopus subject areas

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Influence of Surface Properties of New Biomaterials for Catheters on Bacterial Adhesion Urine

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Zhao, Qi

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Mechanisms of the Enhanced Antibacterial Effect of Ag-TiO₂ Coatings