Mechanistic and Structural Features of PROTAC Ternary Complexes

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• Finished

  Novel PROTAC-based Chemical Biology Approaches to Induced Protein Knockdown Across the Proteome (PhD Studentship - with Boehringer Ingelheim)

  Ciulli, A. (Investigator) & Sapkota, G. (Investigator)

  1/09/18 → 2/09/22

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Proteolysis 86%
  • Bromodomain-containing Protein 4 (BRD4) 70%
  • Ternary Complex 40%
  • Structural Features 40%

• DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/13 → 30/04/18

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Ubiquitin Ligase 93%
  • Proteolysis 80%
  • Von Hippel-Lindau 62%
  • E3 Ubiquitin Ligase 59%