Mechanistic interplay between ceramide and insulin resistance

Federico Reali, Melissa J. Morine, Ozan Kahramanoä Ullarl, Suryaprakash Raichur, Hans Christoph Schneider, Daniel Crowther, Corrado Priami

Research output: Contribution to journalArticle

10 Citations (Scopus)
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Abstract

Recent research adds to a growing body of literature on the essential role of ceramides in glucose homeostasis and insulin signaling, while the mechanistic interplay between various components of ceramide metabolism remains to be quantified. We present an extended model of C16:0 ceramide production through both the de novo synthesis and the salvage pathways. We verify our model with a combination of published models and independent experimental data. In silico experiments of the behavior of ceramide and related bioactive lipids in accordance with the observed transcriptomic changes in obese/diabetic murine macrophages at 5 and 16 weeks support the observation of insulin resistance only at the later phase. Our analysis suggests the pivotal role of ceramide synthase, serine palmitoyltransferase and dihydroceramide desaturase involved in the de novo synthesis and the salvage pathways in influencing insulin resistance versus its regulation.

Original languageEnglish
Article number41231
Number of pages9
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 23 Jan 2017

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Ceramides
Insulin Resistance
Serine C-Palmitoyltransferase
Computer Simulation
Homeostasis
Theoretical Models
Macrophages
Observation
Insulin
Lipids
Glucose
Research
dihydroceramide desaturase

Cite this

Reali, F., Morine, M. J., Kahramanoä Ullarl, O., Raichur, S., Schneider, H. C., Crowther, D., & Priami, C. (2017). Mechanistic interplay between ceramide and insulin resistance. Scientific Reports, 7, [41231]. https://doi.org/10.1038/srep41231
Reali, Federico ; Morine, Melissa J. ; Kahramanoä Ullarl, Ozan ; Raichur, Suryaprakash ; Schneider, Hans Christoph ; Crowther, Daniel ; Priami, Corrado. / Mechanistic interplay between ceramide and insulin resistance. In: Scientific Reports. 2017 ; Vol. 7.
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Reali, F, Morine, MJ, Kahramanoä Ullarl, O, Raichur, S, Schneider, HC, Crowther, D & Priami, C 2017, 'Mechanistic interplay between ceramide and insulin resistance', Scientific Reports, vol. 7, 41231. https://doi.org/10.1038/srep41231

Mechanistic interplay between ceramide and insulin resistance. / Reali, Federico; Morine, Melissa J.; Kahramanoä Ullarl, Ozan; Raichur, Suryaprakash; Schneider, Hans Christoph; Crowther, Daniel; Priami, Corrado.

In: Scientific Reports, Vol. 7, 41231, 23.01.2017.

Research output: Contribution to journalArticle

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Reali F, Morine MJ, Kahramanoä Ullarl O, Raichur S, Schneider HC, Crowther D et al. Mechanistic interplay between ceramide and insulin resistance. Scientific Reports. 2017 Jan 23;7. 41231. https://doi.org/10.1038/srep41231