Medicinal Chemistry of Hybrids for Neurodegenerative Diseases

Elisa Uliassi, Federica Prati, Salvatore Bongarzone, Maria Laura Bolognesi

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)


Introduced more than 50 years ago, molecular hybridization remains one of the most rewarding approaches when searching for new molecules against neurodegeneration. This is because hybrids ligands, which finely integrate two pharmacophoric functionalities, are inherently more adequate to face the complex and multifactorial nature of such maladies. Indeed, both Alzheimer's disease and prion diseases are multifactorial neurodegenerative disorders with several target proteins contributing to their etiology. In this chapter we discuss selected examples of hybrid compounds rationally designed to hit more than one target involved in the neurotoxic cascade, which may hold great promise for the development of new and effective drugs. There are several medicinal chemistry challenges to overcome, but the potential benefits are worth the efforts.

Original languageEnglish
Title of host publicationDesign of Hybrid Molecules for Drug Development
EditorsMichael Decker
PublisherElsevier Inc.
Number of pages19
ISBN (Electronic)9780081011188
ISBN (Print)9780081010112
Publication statusPublished - Apr 2017


  • Alzheimer's disease
  • Clioquinol
  • Donepezil
  • Framework combination
  • Lipoic acid
  • Neurodegeneration
  • Prion diseases
  • Quinone
  • Tacrine

ASJC Scopus subject areas

  • General Chemistry


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