Medium term repeatability for airwave oscillometry in severe asthma patients taking benralizumab

Rory Chan (Lead / Corresponding author), Brian Lipworth

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
17 Downloads (Pure)

Abstract

Background: The effort independent tidal breathing test used by oscillometry presents a viable alternative for following up patients who are stable on biologic therapy.

Objective: We aimed to determine intra- and inter-session repeatability values for airwave oscillometry (AOS) and spirometry in patients who were already taking benralizumab.

Methods: 21 patients with severe eosinophilic asthma attended the Scottish Centre for Respiratory Research as part of a clinical trial (EudraCT number 2019-003763-22). Paired AOS and spirometry values were obtained at three separate visits (baseline, days 28 and 56) with no change in asthma therapy.

Results: Intra-session agreement between repeated measurements for AOS and spirometry were excellent (intraclass correlation coefficients (ICC) ≥0.90) at all three visits. Inter-session agreements were also excellent (ICC ≥0.80).

Conclusion: In this study we report medium term intra- and inter-session repeatability values for airwave oscillometry and spirometry in a cohort of severe asthmatics taking benralizumab therapy. Oscillometry can be used to follow up asthma patients taking biologics.
Original languageEnglish
Article number100119
Number of pages4
JournalJournal of Allergy and Clinical Immunology: Global
Volume2
Issue number3
Early online date26 May 2023
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Benralizumab
  • airway oscillometry
  • asthma
  • repeatability

ASJC Scopus subject areas

  • Immunology and Allergy

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