Medium term repeatability for airwave oscillometry in severe asthma patients taking benralizumab

Background: The effort independent tidal breathing test used by oscillometry presents a viable alternative for following up patients who are stable on biologic therapy.

Objective: We aimed to determine intra- and inter-session repeatability values for airwave oscillometry (AOS) and spirometry in patients who were already taking benralizumab.

Methods: 21 patients with severe eosinophilic asthma attended the Scottish Centre for Respiratory Research as part of a clinical trial (EudraCT number 2019-003763-22). Paired AOS and spirometry values were obtained at three separate visits (baseline, days 28 and 56) with no change in asthma therapy.

Results: Intra-session agreement between repeated measurements for AOS and spirometry were excellent (intraclass correlation coefficients (ICC) ≥0.90) at all three visits. Inter-session agreements were also excellent (ICC ≥0.80).

Conclusion: In this study we report medium term intra- and inter-session repeatability values for airwave oscillometry and spirometry in a cohort of severe asthmatics taking benralizumab therapy. Oscillometry can be used to follow up asthma patients taking biologics.