Medium term repeatability for airwave oscillometry in severe asthma patients taking benralizumab

TY - JOUR

T1 - Medium term repeatability for airwave oscillometry in severe asthma patients taking benralizumab

AU - Chan, Rory

AU - Lipworth, Brian

N1 - Copyright: © 2023 The Author(s). Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.

PY - 2023/8

Y1 - 2023/8

N2 - Background: The effort independent tidal breathing test used by oscillometry presents a viable alternative for following up patients who are stable on biologic therapy. Objective: We aimed to determine intra- and inter-session repeatability values for airwave oscillometry (AOS) and spirometry in patients who were already taking benralizumab. Methods: 21 patients with severe eosinophilic asthma attended the Scottish Centre for Respiratory Research as part of a clinical trial (EudraCT number 2019-003763-22). Paired AOS and spirometry values were obtained at three separate visits (baseline, days 28 and 56) with no change in asthma therapy. Results: Intra-session agreement between repeated measurements for AOS and spirometry were excellent (intraclass correlation coefficients (ICC) ≥0.90) at all three visits. Inter-session agreements were also excellent (ICC ≥0.80). Conclusion: In this study we report medium term intra- and inter-session repeatability values for airwave oscillometry and spirometry in a cohort of severe asthmatics taking benralizumab therapy. Oscillometry can be used to follow up asthma patients taking biologics.

AB - Background: The effort independent tidal breathing test used by oscillometry presents a viable alternative for following up patients who are stable on biologic therapy. Objective: We aimed to determine intra- and inter-session repeatability values for airwave oscillometry (AOS) and spirometry in patients who were already taking benralizumab. Methods: 21 patients with severe eosinophilic asthma attended the Scottish Centre for Respiratory Research as part of a clinical trial (EudraCT number 2019-003763-22). Paired AOS and spirometry values were obtained at three separate visits (baseline, days 28 and 56) with no change in asthma therapy. Results: Intra-session agreement between repeated measurements for AOS and spirometry were excellent (intraclass correlation coefficients (ICC) ≥0.90) at all three visits. Inter-session agreements were also excellent (ICC ≥0.80). Conclusion: In this study we report medium term intra- and inter-session repeatability values for airwave oscillometry and spirometry in a cohort of severe asthmatics taking benralizumab therapy. Oscillometry can be used to follow up asthma patients taking biologics.

KW - Benralizumab

KW - airway oscillometry

KW - asthma

KW - repeatability

UR - https://www.scopus.com/pages/publications/85162884140

U2 - 10.1016/j.jacig.2023.100119

DO - 10.1016/j.jacig.2023.100119

M3 - Article

C2 - 37779519

SN - 2772-8293

VL - 2

JO - Journal of Allergy and Clinical Immunology: Global

JF - Journal of Allergy and Clinical Immunology: Global

IS - 3

M1 - 100119

ER -