Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Lijun Wang; Yue Min; Doudou Xu; Fengjiao Yu; Wuzong Zhou; Alfred Cuschieri

doi:10.1039/c4cc03082f

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Lijun Wang (Lead / Corresponding author), Yue Min, Doudou Xu, Fengjiao Yu, Wuzong Zhou, Alfred Cuschieri

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We report that FeO nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

Original language	English
Pages (from-to)	11147-11150
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	76
DOIs	https://doi.org/10.1039/c4cc03082f
Publication status	Published - 4 Oct 2014

Access to Document

10.1039/c4cc03082f

Cite this

@article{ff6c4676edb841a39d918e1dbc8e60c1,

title = "Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles",

abstract = "We report that FeO nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.",

author = "Lijun Wang and Yue Min and Doudou Xu and Fengjiao Yu and Wuzong Zhou and Alfred Cuschieri",

year = "2014",

month = oct,

day = "4",

doi = "10.1039/c4cc03082f",

language = "English",

volume = "50",

pages = "11147--11150",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "76",

}

TY - JOUR

T1 - Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

AU - Wang, Lijun

AU - Min, Yue

AU - Xu, Doudou

AU - Yu, Fengjiao

AU - Zhou, Wuzong

AU - Cuschieri, Alfred

PY - 2014/10/4

Y1 - 2014/10/4

N2 - We report that FeO nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

AB - We report that FeO nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

UR - http://www.scopus.com/inward/record.url?scp=84906710735&partnerID=8YFLogxK

U2 - 10.1039/c4cc03082f

DO - 10.1039/c4cc03082f

M3 - Article

AN - SCOPUS:84906710735

SN - 1359-7345

VL - 50

SP - 11147

EP - 11150

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Abstract

Access to Document

Other files and links

Fingerprint

Cuschieri, Alfred

Cite this

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

Abstract

Access to Document

Other files and links

Fingerprint

Profiles

Cuschieri, Alfred

Cite this