TY - JOUR
T1 - Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
AU - COGENT Study
AU - Houlston, Richard S.
AU - Webb, Emily
AU - Broderick, Peter
AU - Pittman, Alan M.
AU - Di Bernardo, Maria Chiara
AU - Lubbe, Steven
AU - Chandler, Ian
AU - Vijayakrishnan, Jayaram
AU - Sullivan, Kate
AU - Penegar, Steven
AU - Carvajal-Carmona, Luis
AU - Howarth, Kimberley
AU - Jaeger, Emma
AU - Spain, Sarah L.
AU - Walther, Axel
AU - Barclay, Ella
AU - Martin, Lynn
AU - Gorman, Maggie
AU - Domingo, Enric
AU - Teixeira, Ana S.
AU - Kerr, David
AU - Cazier, Jean Baptiste
AU - Niittymäki, Iina
AU - Tuupanen, Sari
AU - Karhu, Auli
AU - Aaltonen, Lauri A.
AU - Tomlinson, Ian P. M.
AU - Farrington, Susan M.
AU - Tenesa, Albert
AU - Prendergast, James G.D.
AU - Barnetson, Rebecca A.
AU - Cetnarskyj, Roseanne
AU - Porteous, Mary E.
AU - Pharoah, Paul D. P.
AU - Koessler, Thibaud
AU - Hampe, Jochen
AU - Buch, Stephan
AU - Schafmayer, Clemens
AU - Tepel, Jurgen
AU - Schreiber, Stefan
AU - Völzke, Henry
AU - Chang-Claude, Jenny
AU - Hoffmeister, Michael
AU - Brenner, Hermann
AU - Zanke, Brent W.
AU - Montpetit, Alexandre
AU - Hudson, Thomas J.
AU - Gallinger, Steven
AU - Campbell, Harry
AU - Dunlop, Malcolm G.
PY - 2008/12
Y1 - 2008/12
N2 - Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 × 10-10), 16q22.1 (rs9929218, CDH1; P = 1.2 × 10-8), 19q13.1 (rs10411210, RHPN2; P = 4.6 × 10-9) and 20p12.3 (rs961253; P = 2.0 × 10-10). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
AB - Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 × 10-10), 16q22.1 (rs9929218, CDH1; P = 1.2 × 10-8), 19q13.1 (rs10411210, RHPN2; P = 4.6 × 10-9) and 20p12.3 (rs961253; P = 2.0 × 10-10). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.
UR - http://www.scopus.com/inward/record.url?scp=56749176944&partnerID=8YFLogxK
U2 - 10.1038/ng.262
DO - 10.1038/ng.262
M3 - Article
C2 - 19011631
AN - SCOPUS:56749176944
SN - 1061-4036
VL - 40
SP - 1426
EP - 1435
JO - Nature Genetics
JF - Nature Genetics
IS - 12
ER -
