Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast

B. Ansari; S. A. Ogston; C. A. Purdie; D. J. Adamson; D. C. Brown; A. M. Thompson

doi:10.1002/bjs.6162

Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast

B. Ansari (Lead / Corresponding author), S. A. Ogston, C. A. Purdie, D. J. Adamson, D. C. Brown, A. M. Thompson

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Background: The need for sentinel lymph node (SLN) biopsy in patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) is debated. Advocates recommend such biopsy based on a high incidence of SLN involvement in some series. Opponents discourage SLN biopsy based on a perceived low incidence of nodal involvement in this setting. These contradictory arguments are generally based on small studies. The present study is a meta-analysis of the reported data on the incidence of SLN metastasis in patients with DCIS.

Methods. A search of electronic databases identified studies reporting the frequency of SLN metastases in DCIS. The random-effects method was used to combine data.

Results: Twenty-two published series were included in the meta-analysis. The estimate for the incidence of SLN metastases in patients with a preoperative diagnosis of DCIS was 7.4 (95 per cent confidence interval (c.i.) 6.2 to 8.9) per cent compared with 3.7 (95 per cent c.i. 2.8 to 4.8) per cent in patients with a definitive (postoperative) diagnosis of DCIS alone. This was a significant difference with an odds ratio of 2.11 (95 per cent c.i. 1.15 to 2.93).

Conclusion: Patients with a preoperative diagnosis of DCIS should be considered for SLN biopsy.

Original language	English
Pages (from-to)	547-554
Number of pages	8
Journal	British Journal of Surgery
Volume	95
Issue number	5
DOIs	https://doi.org/10.1002/bjs.6162
Publication status	Published - May 2008

Keywords

Core needle biopsy
Lymph node
Cancer
Diagnosis
Invasion
Risk
Predictors
Management
Recommendations
Positivity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast",

abstract = "Background: The need for sentinel lymph node (SLN) biopsy in patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) is debated. Advocates recommend such biopsy based on a high incidence of SLN involvement in some series. Opponents discourage SLN biopsy based on a perceived low incidence of nodal involvement in this setting. These contradictory arguments are generally based on small studies. The present study is a meta-analysis of the reported data on the incidence of SLN metastasis in patients with DCIS.Methods. A search of electronic databases identified studies reporting the frequency of SLN metastases in DCIS. The random-effects method was used to combine data.Results: Twenty-two published series were included in the meta-analysis. The estimate for the incidence of SLN metastases in patients with a preoperative diagnosis of DCIS was 7.4 (95 per cent confidence interval (c.i.) 6.2 to 8.9) per cent compared with 3.7 (95 per cent c.i. 2.8 to 4.8) per cent in patients with a definitive (postoperative) diagnosis of DCIS alone. This was a significant difference with an odds ratio of 2.11 (95 per cent c.i. 1.15 to 2.93).Conclusion: Patients with a preoperative diagnosis of DCIS should be considered for SLN biopsy.",

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AU - Ansari, B.

AU - Ogston, S. A.

AU - Purdie, C. A.

AU - Adamson, D. J.

AU - Brown, D. C.

AU - Thompson, A. M.

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N2 - Background: The need for sentinel lymph node (SLN) biopsy in patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) is debated. Advocates recommend such biopsy based on a high incidence of SLN involvement in some series. Opponents discourage SLN biopsy based on a perceived low incidence of nodal involvement in this setting. These contradictory arguments are generally based on small studies. The present study is a meta-analysis of the reported data on the incidence of SLN metastasis in patients with DCIS.Methods. A search of electronic databases identified studies reporting the frequency of SLN metastases in DCIS. The random-effects method was used to combine data.Results: Twenty-two published series were included in the meta-analysis. The estimate for the incidence of SLN metastases in patients with a preoperative diagnosis of DCIS was 7.4 (95 per cent confidence interval (c.i.) 6.2 to 8.9) per cent compared with 3.7 (95 per cent c.i. 2.8 to 4.8) per cent in patients with a definitive (postoperative) diagnosis of DCIS alone. This was a significant difference with an odds ratio of 2.11 (95 per cent c.i. 1.15 to 2.93).Conclusion: Patients with a preoperative diagnosis of DCIS should be considered for SLN biopsy.

AB - Background: The need for sentinel lymph node (SLN) biopsy in patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) is debated. Advocates recommend such biopsy based on a high incidence of SLN involvement in some series. Opponents discourage SLN biopsy based on a perceived low incidence of nodal involvement in this setting. These contradictory arguments are generally based on small studies. The present study is a meta-analysis of the reported data on the incidence of SLN metastasis in patients with DCIS.Methods. A search of electronic databases identified studies reporting the frequency of SLN metastases in DCIS. The random-effects method was used to combine data.Results: Twenty-two published series were included in the meta-analysis. The estimate for the incidence of SLN metastases in patients with a preoperative diagnosis of DCIS was 7.4 (95 per cent confidence interval (c.i.) 6.2 to 8.9) per cent compared with 3.7 (95 per cent c.i. 2.8 to 4.8) per cent in patients with a definitive (postoperative) diagnosis of DCIS alone. This was a significant difference with an odds ratio of 2.11 (95 per cent c.i. 1.15 to 2.93).Conclusion: Patients with a preoperative diagnosis of DCIS should be considered for SLN biopsy.

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KW - Invasion

KW - Risk

KW - Predictors

KW - Management

KW - Recommendations

KW - Positivity

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Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast

Abstract

Keywords

UN SDGs

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