Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

S. H. Rossi; R. Hsu; C. Blick; V. Goh; P. Nathan; D. Nicol; S. Fleming; M. Sweeting; E. C. F. Wilson; G. D. Stewart

doi:10.1002/bjs.10523

Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

S. H. Rossi, R. Hsu, C. Blick, V. Goh, P. Nathan, D. Nicol, S. Fleming, M. Sweeting, E. C. F. Wilson, G. D. Stewart (Lead / Corresponding author)

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

BACKGROUND: The potential for an ultrasound-based screening programme for renal cell carcinoma (RCC) to improve survival through early detection has been the subject of much debate. The prevalence of ultrasound-detected asymptomatic RCC is an important first step to establishing whether a screening programme may be feasible.

METHODS: A systematic search of MEDLINE and Embase was performed up to March 2016 to identify studies reporting the prevalence of renal masses and RCC. Two populations of patients were chosen: asymptomatic individuals undergoing screening ultrasonography and patients undergoing ultrasonography for abdominal symptoms not related to RCC. A random-effects meta-analysis was performed. Study quality was evaluated using a validated eight-point checklist.

RESULTS: Sixteen studies (413 551 patients) were included in the final analysis. The pooled prevalence of renal mass was 0·36 (95 per cent c.i. 0·23 to 0·52) per cent and the prevalence of histologically proven RCC was 0·10 (0·06 to 0·15) per cent. The prevalence of RCC was more than double in studies from Europe and North America than in those from Asia: 0·17 (0·09 to 0·27) versus 0·06 (0·03 to 0·09) per cent respectively. Data on 205 screen-detected RCCs showed that 84·4 per cent of tumours were stage T1-T2 N0, 13·7 per cent were T3-T4 N0, and only 2·0 per cent had positive nodes or metastases at diagnosis.

CONCLUSION: At least one RCC would be detected per 1000 individuals screened. The majority of tumours identified are early stage (T1-T2).

Original language	English
Pages (from-to)	648-659
Number of pages	12
Journal	British Journal of Surgery
Volume	104
Issue number	6
Early online date	13 Apr 2017
DOIs	https://doi.org/10.1002/bjs.10523
Publication status	Published - May 2017

Keywords

Journal article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{11d0b032fc574eef8072788ee57fe6ac,

title = "Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography",

abstract = "BACKGROUND: The potential for an ultrasound-based screening programme for renal cell carcinoma (RCC) to improve survival through early detection has been the subject of much debate. The prevalence of ultrasound-detected asymptomatic RCC is an important first step to establishing whether a screening programme may be feasible.METHODS: A systematic search of MEDLINE and Embase was performed up to March 2016 to identify studies reporting the prevalence of renal masses and RCC. Two populations of patients were chosen: asymptomatic individuals undergoing screening ultrasonography and patients undergoing ultrasonography for abdominal symptoms not related to RCC. A random-effects meta-analysis was performed. Study quality was evaluated using a validated eight-point checklist.RESULTS: Sixteen studies (413 551 patients) were included in the final analysis. The pooled prevalence of renal mass was 0·36 (95 per cent c.i. 0·23 to 0·52) per cent and the prevalence of histologically proven RCC was 0·10 (0·06 to 0·15) per cent. The prevalence of RCC was more than double in studies from Europe and North America than in those from Asia: 0·17 (0·09 to 0·27) versus 0·06 (0·03 to 0·09) per cent respectively. Data on 205 screen-detected RCCs showed that 84·4 per cent of tumours were stage T1-T2 N0, 13·7 per cent were T3-T4 N0, and only 2·0 per cent had positive nodes or metastases at diagnosis.CONCLUSION: At least one RCC would be detected per 1000 individuals screened. The majority of tumours identified are early stage (T1-T2).",

keywords = "Journal article, Review",

author = "Rossi, {S. H.} and R. Hsu and C. Blick and V. Goh and P. Nathan and D. Nicol and S. Fleming and M. Sweeting and Wilson, {E. C. F.} and Stewart, {G. D.}",

note = "The authors acknowledge the Urology Foundation, which provided a travel grant for S.H.R. covering the cost of a course on performing meta-analyses, and the Renal Cancer Research Fund for providing a grant for S.H.R. to attend a health economics course. E.C.F.W. is funded by the NIHR Cambridge Biomedi- cal Research Centre and S.H.R. is funded by an NIHR Academic Clinical Fellowship. There are no other sources of funding.",

year = "2017",

month = may,

doi = "10.1002/bjs.10523",

language = "English",

volume = "104",

pages = "648--659",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

AU - Rossi, S. H.

AU - Hsu, R.

AU - Blick, C.

AU - Goh, V.

AU - Nathan, P.

AU - Nicol, D.

AU - Fleming, S.

AU - Sweeting, M.

AU - Wilson, E. C. F.

AU - Stewart, G. D.

N1 - The authors acknowledge the Urology Foundation, which provided a travel grant for S.H.R. covering the cost of a course on performing meta-analyses, and the Renal Cancer Research Fund for providing a grant for S.H.R. to attend a health economics course. E.C.F.W. is funded by the NIHR Cambridge Biomedi- cal Research Centre and S.H.R. is funded by an NIHR Academic Clinical Fellowship. There are no other sources of funding.

PY - 2017/5

Y1 - 2017/5

N2 - BACKGROUND: The potential for an ultrasound-based screening programme for renal cell carcinoma (RCC) to improve survival through early detection has been the subject of much debate. The prevalence of ultrasound-detected asymptomatic RCC is an important first step to establishing whether a screening programme may be feasible.METHODS: A systematic search of MEDLINE and Embase was performed up to March 2016 to identify studies reporting the prevalence of renal masses and RCC. Two populations of patients were chosen: asymptomatic individuals undergoing screening ultrasonography and patients undergoing ultrasonography for abdominal symptoms not related to RCC. A random-effects meta-analysis was performed. Study quality was evaluated using a validated eight-point checklist.RESULTS: Sixteen studies (413 551 patients) were included in the final analysis. The pooled prevalence of renal mass was 0·36 (95 per cent c.i. 0·23 to 0·52) per cent and the prevalence of histologically proven RCC was 0·10 (0·06 to 0·15) per cent. The prevalence of RCC was more than double in studies from Europe and North America than in those from Asia: 0·17 (0·09 to 0·27) versus 0·06 (0·03 to 0·09) per cent respectively. Data on 205 screen-detected RCCs showed that 84·4 per cent of tumours were stage T1-T2 N0, 13·7 per cent were T3-T4 N0, and only 2·0 per cent had positive nodes or metastases at diagnosis.CONCLUSION: At least one RCC would be detected per 1000 individuals screened. The majority of tumours identified are early stage (T1-T2).

AB - BACKGROUND: The potential for an ultrasound-based screening programme for renal cell carcinoma (RCC) to improve survival through early detection has been the subject of much debate. The prevalence of ultrasound-detected asymptomatic RCC is an important first step to establishing whether a screening programme may be feasible.METHODS: A systematic search of MEDLINE and Embase was performed up to March 2016 to identify studies reporting the prevalence of renal masses and RCC. Two populations of patients were chosen: asymptomatic individuals undergoing screening ultrasonography and patients undergoing ultrasonography for abdominal symptoms not related to RCC. A random-effects meta-analysis was performed. Study quality was evaluated using a validated eight-point checklist.RESULTS: Sixteen studies (413 551 patients) were included in the final analysis. The pooled prevalence of renal mass was 0·36 (95 per cent c.i. 0·23 to 0·52) per cent and the prevalence of histologically proven RCC was 0·10 (0·06 to 0·15) per cent. The prevalence of RCC was more than double in studies from Europe and North America than in those from Asia: 0·17 (0·09 to 0·27) versus 0·06 (0·03 to 0·09) per cent respectively. Data on 205 screen-detected RCCs showed that 84·4 per cent of tumours were stage T1-T2 N0, 13·7 per cent were T3-T4 N0, and only 2·0 per cent had positive nodes or metastases at diagnosis.CONCLUSION: At least one RCC would be detected per 1000 individuals screened. The majority of tumours identified are early stage (T1-T2).

KW - Journal article

KW - Review

U2 - 10.1002/bjs.10523

DO - 10.1002/bjs.10523

M3 - Review article

C2 - 28407225

SN - 0007-1323

VL - 104

SP - 648

EP - 659

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 6

ER -

Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

Abstract

Keywords

UN SDGs

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